Cytokeratin 6 Antibody (LHK 6): sc-53260

Cytokeratin 6 Antibody (LHK 6) is a mouse monoclonal IgG2a antibody that detects cytokeratin 6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 6 is a vital member of the cytokeratin family, which consists of intermediate filament proteins crucial for maintaining structural integrity and function of epithelial cells. Anti-cytokeratin 6 antibody (LHK 6) recognizes proteins predominantly located in epithelial cell cytoplasm, where a network forms to provide mechanical support and stress resilience. Cytokeratin 6 plays a significant role in keratinocyte differentiation and epidermal health, particularly in skin and hair. Cytokeratin 6 serves as a valuable biomarker for various epithelial tumors, aiding in malignancy diagnosis and characterization. The gene encoding human cytokeratin 6A, the dominant isoform in epithelial tissues, is located on chromosome 12q13, and mutations can lead to inherited skin and hair disorders. Anti-cytokeratin 6 antibody (LHK 6) serves as an essential tool for researchers studying epithelial biology and related pathologies, providing insights into tissue differentiation and disease progression.

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Cytokeratin 6 Antibody (LHK 6) References:

1. Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery.  |  Katwal, AB., et al. 2013. Gene Ther. 20: 930-8. PMID: 23535898
2. A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth.  |  Lebron, MB., et al. 2014. Cancer Biol Ther. 15: 1208-18. PMID: 24921944
3. Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.  |  Tancharoen, S., et al. 2015. PLoS One. 10: e0117775. PMID: 25688865
4. The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells.  |  Helland, T., et al. 2015. PLoS One. 10: e0122339. PMID: 25867603
5. Therapeutic Efficacy Assessment of CK6, a Monoclonal KIT Antibody, in a Panel of Gastrointestinal Stromal Tumor Xenograft Models.  |  Van Looy, T., et al. 2015. Transl Oncol. 8: 112-8. PMID: 25926077
6. Cytokeratin 5 and cytokeratin 6 expressions are unconnected in normal and cancerous tissues and have separate diagnostic implications.  |  Völkel, C., et al. 2022. Virchows Arch. 480: 433-447. PMID: 34559291
7. Immunological Effects of Recombinant Lactobacillus casei Expressing IHNV G Protein and Rainbow Trout (Oncorhynchus mykiss) Chemokine CK6 as an Oral Vaccine.  |  Sun, J., et al. 2022. Front Immunol. 13: 927443. PMID: 35784302
8. Cytokeratin 6 identifies basal-like subtypes of pancreatic ductal adenocarcinoma with decreased survival.  |  Lyu, SI., et al. 2023. J Cancer Res Clin Oncol. 149: 7539-7546. PMID: 36971797
9. Expression of hornerin in skin lesions of atopic dermatitis and skin diseases.  |  Makino, T., et al. 2024. Clin Exp Dermatol. 49: 255-258. PMID: 38123340
10. Intermediate Filaments in Breast Cancer Progression, and Potential Biomarker for Cancer Therapy: A Narrative Review.  |  Shalannandia, WA., et al. 2024. Breast Cancer (Dove Med Press). 16: 689-704. PMID: 39430570

The preferred Cytokeratin 6/75 antibody is Cytokeratin 6/75 Antibody (H-6): sc-166074.