Cytokeratin 4 Antibody (6B10): sc-52321

Cytokeratin 4 Antibody (6B10) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 4 protein of mouse, rat, human, hamster, and guinea pig origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Cytokeratin 4 antibody (6B10) is available as the non-conjugated format. Cytokeratin 4, also known as KRT4, plays a crucial role in maintaining epithelial cell structural integrity, particularly in mucosal and esophageal epithelia, where KRT4 is co-expressed with Cytokeratin 13. Cytokeratin 4 protein forms a resilient barrier against mechanical stress and environmental insults, protecting underlying tissues and maintaining homeostasis. Cytokeratin 4 expression indicates epithelial differentiation and helps distinguish various epithelial malignancies in clinical settings, as KRT4 expression patterns provide insights into tumor origin and differentiation status. Anti-Cytokeratin 4 antibody (6B10) reacts with multiple species and works across various applications, making this clone an invaluable tool for studying epithelial biology and pathology.

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Cytokeratin 4 Antibody (6B10) References:

1. K15 expression implies lateral differentiation within stratified epithelial basal cells.  |  Porter, RM., et al. 2000. Lab Invest. 80: 1701-10. PMID: 11092530
2. Alterations in cytokeratin expression precede histological changes in epithelia of vitamin A-deficient rats.  |  Gijbels, MJ., et al. 1992. Cell Tissue Res. 268: 197-203. PMID: 1379888
3. An investigation of cytokeratin expression in skin epithelial cysts and some uncommon types of cystic tumours using chain-specific antibodies.  |  Broekaert, D., et al. 1990. Arch Dermatol Res. 282: 383-91. PMID: 1701984
4. Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13.  |  van Muijen, GN., et al. 1986. Exp Cell Res. 162: 97-113. PMID: 2415382
5. Differentiation-related changes of cytokeratin expression in cultured keratinocytes and in fetal, newborn, and adult epidermis.  |  Van Muijen, GN., et al. 1987. Exp Cell Res. 171: 331-45. PMID: 2442018
6. Comparative analysis of the expression of involucrin, filaggrin and cytokeratin 4, 10, 16 in cholesteatoma.  |  Min, HJ., et al. 2012. Korean J Audiol. 16: 124-9. PMID: 24653886
7. Evaluation of a new tumor marker for cytokeratin 8 and 18 fragments in healthy individuals and prostate cancer patients.  |  Silén, A., et al. 1994. Prostate. 24: 326-32. PMID: 7516071
8. A novel IRMA and ELISA for quantifying cytokeratin 8 and 18 fragments in the sera of healthy individuals and cancer patients.  |  Silén, A., et al. 1995. Scand J Clin Lab Invest. 55: 153-61. PMID: 7545308
9. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview.  |  van der Velden, LA., et al. 1993. Head Neck. 15: 133-46. PMID: 7680025
10. Serum and tissue distribution of a fragment of cytokeratin 19 (cyfra 21-1) in lung cancer patients.  |  Quillien, V., et al. 1995. Anticancer Res. 15: 2857-63. PMID: 8669879
11. Functional inactivation of p53 by antisense RNA induces invasive ability of lung carcinoma cells and downregulates cytokeratin synthesis.  |  Mukhopadhyay, T. and Roth, JA. 1996. Anticancer Res. 16: 1683-9. PMID: 8712687
12. Cytokeratin expression, fibrillar organization, and subtle function in liver cells.  |  Marceau, N. and Loranger, A. 1995. Biochem Cell Biol. 73: 619-25. PMID: 8714681

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 4 Antibody (6B10) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 4 Antibody (6B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 4 Antibody (6B10) Specifications

Alternate Product Name: Keratin 4

Product Clone Name: 6B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target:

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 4

Species Reactivity/Detection: mouse, rat, human, hamster, Guinea pig

Additional Mammalian Reactivity: porcine, caprine, feline and canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 4 Antibody (6B10): N/A