Cytokeratin 17 Antibody (D-4): sc-393091

Cytokeratin 17 Antibody (D-4) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 17 (CK17) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CK17 is a member of the Cytokeratin subfamily of intermediate filament proteins, consisting of 432 amino acids, and is predominantly expressed in basal cells of complex epithelia, such as those found in nail bed, hair follicle, and sebaceous glands, while being absent in stratified or simple epithelia. CK17′s unique expression pattern is crucial for regulating cell growth and size, as CK17 interacts with adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in CK17 can lead to impaired protein translation and reduced size of skin keratinocytes, which is associated with decreased Akt/mTOR signaling activity. CK17 serves as a valuable marker for identifying cervical stem cells, as well as for diagnosing squamous cell carcinoma of the larynx, respiratory syncytial virus infections, and transitional cell carcinomas of the human urinary tract. Anti-Cytokeratin 17 antibody (D-4) is an essential tool for researchers studying epithelial biology and related pathologies.

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Cytokeratin 17 Antibody (D-4) References:

1. Characterization of the human gene encoding cytokeratin 17 and its expression pattern.  |  Troyanovsky, SM., et al. 1992. Eur J Cell Biol. 59: 127-37. PMID: 1281771
2. Cytokeratin 17 mRNA expression has potential for diagnostic marker of oral squamous cell carcinoma.  |  Toyoshima, T., et al. 2008. J Cancer Res Clin Oncol. 134: 515-21. PMID: 17786476
3. Overexpression of cytokeratin 17 protein in oral squamous cell carcinoma in vitro and in vivo.  |  Wei, KJ., et al. 2009. Oral Dis. 15: 111-7. PMID: 18992022
4. Evaluation of superficial oral squamous cell malignancy based on morphometry and immunoexpression of cytokeratin 13 and cytokeratin 17.  |  Yamashina, M., et al. 2014. Acta Cytol. 58: 67-75. PMID: 24247036
5. Inhibition of JNK in HaCaT cells induced tight junction formation with decreased expression of cytokeratin 5, cytokeratin 17 and desmoglein 3.  |  Kitagawa, N., et al. 2014. Histochem Cell Biol. 142: 389-99. PMID: 24714933
6. Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma.  |  Goyal, A., et al. 2016. J Cutan Pathol. 43: 422-9. PMID: 26968559
7. A Clinicopathological Approach to Odontogenic Cysts: the Role of Cytokeratin 17 and bcl2 Immunohistochemistry in Identifying Odontogenic Keratocysts.  |  Cserni, D., et al. 2020. Pathol Oncol Res. 26: 2613-2620. PMID: 32632899
8. Celery (Apium graveolens) as a potential antibacterial agent and its effect on cytokeratin-17 and other healing promoters in skin wounds infected with methicillin-resistant Staphylococcus aureus.  |  Prakoso, YA., et al. 2020. Vet World. 13: 865-871. PMID: 32636580
9. Activation of the silent human cytokeratin 17 pseudogene-promoter region by cryptic enhancer elements of the cytokeratin 17 gene.  |  Troyanovsky, SM. and Leube, RE. 1994. Eur J Biochem. 225: 61-9. PMID: 7523124
10. Cytokeratin 17 as an immunohistochemical marker for intramural cytotrophoblast in human first trimester uteroplacental arteries.  |  Pröll, J., et al. 1997. Cell Tissue Res. 288: 335-43. PMID: 9082969

The preferred Cytokeratin 17 antibody is Cytokeratin 17 Antibody (E-4): sc-393002.