Cytokeratin 13 Antibody (A-3): sc-390982

Cytokeratin 13 Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 13 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Cytokeratin 13 antibody (A-3) is available in non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Cytokeratin 13 forms a heterotetramer with cytokeratin 4 as a crucial component of the intermediate filament family, primarily located in the cytoskeletal region of non-cornified stratified squamous epithelia. Cytokeratin 13 maintains structural integrity and mechanical resilience of epithelial cells, essential for tissue protection and function. Cytokeratin 13 serves as a marker for epithelial tissue differentiation, proving particularly valuable in studying squamous cell carcinomas where expression patterns indicate tumor characteristics. KRT13 gene defects are linked to white sponge nevus of Cannon, a rare genetic disorder causing soft, white, spongy lesions in the oral mucosa, underscoring Cytokeratin 13′s clinical significance in health and disease.

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Cytokeratin 13 Antibody (A-3) References:

1. Identification of two novel mutations in keratin 13 as the cause of white sponge naevus.  |  Rugg, E., et al. 1999. Oral Dis. 5: 321-4. PMID: 10561721
2. A novel mutation in the keratin 13 gene causing oral white sponge nevus.  |  Terrinoni, A., et al. 2001. J Dent Res. 80: 919-23. PMID: 11379896
3. Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients.  |  Blokx, WA., et al. 2002. Arch Dermatol. 138: 61-5. PMID: 11790168
4. A novel mutation in the keratin 4 gene causing white sponge naevus.  |  Chao, SC., et al. 2003. Br J Dermatol. 148: 1125-8. PMID: 12828738
5. Expression of keratin 13 in human epithelial neoplasms.  |  Malecha, MJ. and Miettinen, M. 1991. Virchows Arch A Pathol Anat Histopathol. 418: 249-54. PMID: 1706547
6. Differential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cells.  |  Sheng, S., et al. 2008. Mol Cell Endocrinol. 296: 1-9. PMID: 18951949
7. Loss of keratin 13 in oral carcinoma in situ: a comparative study of protein and gene expression levels using paraffin sections.  |  Ida-Yonemochi, H., et al. 2012. Mod Pathol. 25: 784-94. PMID: 22301701
8. Krüppel-like Factor 4 Promotes Esophageal Squamous Cell Carcinoma Differentiation by Up-regulating Keratin 13 Expression.  |  He, H., et al. 2015. J Biol Chem. 290: 13567-77. PMID: 25851906
9. Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis.  |  Kobayashi, M., et al. 2024. Int J Mol Sci. 25: PMID: 39684417
10. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus.  |  Richard, G., et al. 1995. Nat Genet. 11: 453-5. PMID: 7493031

The preferred Cytokeratin 13 antibody is Cytokeratin 13 Antibody (A-5): sc-376901.