Cytokeratin 1 Antibody (4D12B3): sc-65999

Cytokeratin 1 Antibody (4D12B3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cytokeratin 1 antibody (4D12B3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratin 1 is a vital member of the cytokeratin family, consisting of intermediate filament proteins crucial for maintaining epithelial cell structural integrity. These proteins are predominantly located in keratinocyte cytoplasm, forming a network that provides mechanical support and resilience to cells under stress. Cytokeratin 1 plays an essential role in the epidermis, constituting a significant portion of keratinocyte cytoskeleton and contributing to skin barrier function. Cytokeratin 1 serves as a key marker for tissue differentiation and helps characterize various malignancies, including epithelioid hemangioendotheliomas, angiosarcomas, schwannomas, epithelioid sarcomas, and synovial sarcomas. Located on chromosome 12q13.13, mutations in the human Cytokeratin 1 gene can lead to abnormal filament associations, resulting in conditions such as epidermolytic hyperkeratosis.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 1 Antibody (4D12B3) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 1 Antibody (4D12B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 1 Antibody (4D12B3) Specifications

Alternate Product Name: Cytokeratin 1

Product Clone Name: 4D12B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Cytokeratin 1

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 1 Antibody (4D12B3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Cytokeratin 1 antibody is Cytokeratin 1 Antibody (E-12): sc-376224.