Cyclophilin 40 Antibody (C-11): sc-137216
- Cyclophilin 40 Antibody (C-11) is a mouse monoclonal IgG2b κ Cyclophilin 40 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 186-370 mapping at the C-terminus of Cyclophilin 40 of human origin
- Cyclophilin 40 Antibody (C-11) is recommended for detection of Cyclophilin 40 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Cyclophilin 40 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Cyclophilin 40 Antibody (C-11) for WB applications. This reagent is now offered in a bundle with Cyclophilin 40 Antibody (C-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Cyclophilin 40 Antibody (C-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Cyclophilin 40 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Cyclophilin 40 antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cyclophilin 40, also known as CyP40, plays a crucial role in protein folding and isomerization, specifically catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, which is essential for proper protein function and stability. Cyclophilin 40 is predominantly located in the cytoplasm, where Cyclophilin 40 interacts with various client proteins, including steroid hormone receptors, thereby influencing their activity and stability. CyP40′s ability to modulate the function of these receptors highlights Cyclophilin 40′s importance in cellular signaling pathways and stress responses, making CyP40 a significant target for research in areas such as cancer and autoimmune diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cyclophilin 40 Antibody (C-11) References:
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. | Gevaert, K., et al. 2003. Nat Biotechnol. 21: 566-9. PMID: 12665801
- Cyclophilin D: knocking on death's door. | Schneider, MD. 2005. Sci STKE. 2005: pe26. PMID: 15942033
- Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. | Schinzel, AC., et al. 2005. Proc Natl Acad Sci U S A. 102: 12005-10. PMID: 16103352
- Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca2+ uptake/ release. | Guo, HX., et al. 2005. Acta Pharmacol Sin. 26: 1201-11. PMID: 16174436
- Cyclophilin 40: an Hsp90-cochaperone associated with apo-steroid receptors. | Ratajczak, T., et al. 2009. Int J Biochem Cell Biol. 41: 1652-5. PMID: 19433306
- Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40. | Park, MS., et al. 2011. Anal Biochem. 410: 257-65. PMID: 21146485
- Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes. | Jandova, J., et al. 2013. Exp Cell Res. 319: 750-60. PMID: 23220213
- Human cyclophilin 40 unravels neurotoxic amyloids. | Baker, JD., et al. 2017. PLoS Biol. 15: e2001336. PMID: 28654636
- Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties. | Gur, M., et al. 2018. J Chem Phys. 148: 145101. PMID: 29655319
- Cyclophilin-40: evidence for a dimeric complex with hsp90. | Hoffmann, K. and Handschumacher, RE. 1995. Biochem J. 307 (Pt 1): 5-8. PMID: 7717993
- Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. | Kieffer, LJ., et al. 1993. J Biol Chem. 268: 12303-10. PMID: 8509368
- The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene. | Yokoi, H., et al. 1996. Genomics. 35: 448-55. PMID: 8812478
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclophilin 40 Antibody (C-11) | sc-137216 | 200 µg/ml | $322.00 | |||
Cyclophilin 40 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-521453 | 200 µg Ab, 40 µg BP | $361.00 | |||
Cyclophilin 40 Antibody (C-11) AC | sc-137216 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Cyclophilin 40 Antibody (C-11) HRP | sc-137216 HRP | 200 µg/ml | $322.00 | |||
Cyclophilin 40 Antibody (C-11) FITC | sc-137216 FITC | 200 µg/ml | $336.00 | |||
Cyclophilin 40 Antibody (C-11) PE | sc-137216 PE | 200 µg/ml | $349.00 | |||
Cyclophilin 40 Antibody (C-11) Alexa Fluor® 488 | sc-137216 AF488 | 200 µg/ml | $364.00 | |||
Cyclophilin 40 Antibody (C-11) Alexa Fluor® 546 | sc-137216 AF546 | 200 µg/ml | $364.00 | |||
Cyclophilin 40 Antibody (C-11) Alexa Fluor® 594 | sc-137216 AF594 | 200 µg/ml | $364.00 | |||
Cyclophilin 40 Antibody (C-11) Alexa Fluor® 647 | sc-137216 AF647 | 200 µg/ml | $364.00 | |||
Cyclophilin 40 Antibody (C-11) Alexa Fluor® 680 | sc-137216 AF680 | 200 µg/ml | $364.00 | |||
Cyclophilin 40 Antibody (C-11) Alexa Fluor® 790 | sc-137216 AF790 | 200 µg/ml | $364.00 |