CUL-3 Antibody (C-3): sc-166054
- CUL-3 Antibody (C-3) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-293 of CUL-3 (cullin-3) of human origin
- recommended for detection of CUL-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CUL-3 Antibody (C-3) for WB applications. These reagents are now offered in bundles with CUL-3 Antibody (C-3) (see ordering information below).
CUL-3 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects CUL-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CUL-3 plays a crucial role in the ubiquitin-proteasome system, specifically in the selective degradation of proteins, which is vital for maintaining cellular homeostasis and regulating various biological processes, including cell cycle progression and signal transduction. CUL-3 forms a part of the E3 ubiquitin ligase complex, where CUL-3 associates with Nedd-8, enhancing activity and facilitating the ubiquitination of target substrates. CUL-3′s ability to regulate protein degradation underscores its importance in cellular functions, as dysregulation can lead to various diseases, including cancer. Anti-CUL-3 antibody (C-3) enables researchers to gain insights into protein turnover dynamics and the implications of cullin-mediated ubiquitination in health and disease.
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CUL-3 Antibody (C-3) References:
- Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications. | Chen, HY., et al. 2016. Cell Div. 11: 5. PMID: 27042198
- Downregulation of autophagy through CUL3-KLHL20-mediated turnover of the ULK1 and PIK3C3/VPS34 complexes. | Feng, Y. and Klionsky, DJ. 2016. Autophagy. 12: 1071-2. PMID: 27096860
- Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3. | Rapanelli, M., et al. 2021. Mol Psychiatry. 26: 1491-1504. PMID: 31455858
- Cul3 is required for normal development of the mammary gland. | Cummings, CM. and Singer, JD. 2021. Cell Tissue Res. 385: 49-63. PMID: 33825963
- Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. | Morandell, J., et al. 2021. Nat Commun. 12: 3058. PMID: 34031387
- SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors. | Umberger, PA. and Ogden, SK. 2021. Front Cell Dev Biol. 9: 710295. PMID: 34395437
- Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma. | Bai, X., et al. 2023. Cell Commun Signal. 21: 242. PMID: 37723559
- Autism risk gene Cul3 alters neuronal morphology via caspase-3 activity in mouse hippocampal neurons. | Xia, QQ., et al. 2024. Front Cell Neurosci. 18: 1320784. PMID: 38803442
- Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3LZTR1 E3 Ligase KRAS Complex. | Piech, S., et al. 2024. ACS Chem Biol. 19: 1942-1952. PMID: 39194017
- Burkholderia pseudomallei BipD initiates mitophagy to evade killing by hijacking host KLHL9-KLHL13-CUL3 E3 ligase to ubiquitinate IMMT. | Nan, D., et al. 2024. Autophagy. 20: 2830-2832. PMID: 39265641
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUL-3 Antibody (C-3) | sc-166054 | 200 µg/ml | $316.00 | |||
CUL-3 Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-537435 | 200 µg Ab; 10 µg BP | $354.00 | |||
CUL-3 Antibody (C-3): m-IgGκ BP-HRP Bundle | sc-534700 | 200 µg Ab; 40 µg BP | $354.00 | |||
CUL-3 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-545184 | 200 µg Ab; 20 µg BP | $354.00 |