CTMP Antibody (H-10): sc-390353

CTMP Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects CTMP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CTMP (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The carboxy-terminal modulator protein (CTMP) plays a crucial role in regulating the Akt signaling pathway, which is vital for cellular processes such as growth, survival, and metabolism. Located in the cytoplasm, CTMP interacts with the C-terminal regulatory domain of Akt, serving as a negative regulator that inhibits the phosphorylation of Akt at serine 473 and threonine 308. This inhibition is significant because aberrant activation of the Akt pathway is frequently associated with various cancers, including glioblastomas, where decreased expression of CTMP due to hypermethylation of its promoter has been linked to tumor progression. By understanding the function and regulatory mechanisms of CTMP, researchers can gain insights into potential therapeutic targets for conditions driven by dysregulated Akt signaling.

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CTMP Antibody (H-10) References:

1. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.  |  Maira, SM., et al. 2001. Science. 294: 374-80. PMID: 11598301
2. Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas.  |  Knobbe, CB., et al. 2004. J Natl Cancer Inst. 96: 483-6. PMID: 15026474
3. Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons.  |  Chae, KS., et al. 2005. J Neurophysiol. 93: 1174-82. PMID: 15509648
4. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.  |  Knobbe, CB., et al. 2005. Neuropathol Appl Neurobiol. 31: 486-90. PMID: 16150119
5. Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis?  |  Martelli, AM., et al. 2006. Cell Signal. 18: 1101-7. PMID: 16516442
6. Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury.  |  Williams, DL., et al. 2006. Shock. 25: 432-9. PMID: 16680006
7. cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: development of a hypothesis based on studies with soluble guanylyl cyclase α(1)β(1).  |  Beste, KY. and Seifert, R. 2013. Biol Chem. 394: 261-70. PMID: 23087103
8. CTMP-based cellulose fibers modified with core-shell latex for reinforcing biocomposites.  |  Pan, Y., et al. 2013. Carbohydr Polym. 95: 428-33. PMID: 23618289
9. CTMP, a predictive biomarker for trastuzumab resistance in HER2-enriched breast cancer patient.  |  Chen, YC., et al. 2017. Oncotarget. 8: 29699-29710. PMID: 27447863
10. Abiotic Synthesis of Nucleoside 5'-Triphosphates with Nickel Borate and Cyclic Trimetaphosphate (CTMP).  |  Kim, HJ. and Benner, SA. 2021. Astrobiology. 21: 298-306. PMID: 33533695
11. Mitochondrial protein LETM1 and its-mediated CTMP are potential therapeutic targets for endometrial cancer.  |  Niu, F., et al. 2022. Anticancer Drugs. 33: 632-641. PMID: 35324530
12. Electrochemical Characteristics of Lignin in CTMP for Paper Battery Electrodes.  |  Isacsson, P., et al. 2024. ChemSusChem. 17: e202400222. PMID: 38874273

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CTMP Antibody (H-10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CTMP Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CTMP Antibody (H-10) Specifications

Alternate Product Name: CTMP

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-137

Epitope Target: CTMP

Epitope Species: human

Product Reactivity/Detection: CTMP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CTMP Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin