CtIP Antibody (F-2): sc-28324
- CtIP Antibody (F-2) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 598-897 of CtIP of human origin
- recommended for detection of CtIP of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CtIP Antibody (F-2) for WB applications. These reagents are now offered in bundles with CtIP Antibody (F-2) (see ordering information below).
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CtIP Antibody (F-2) is a mouse monoclonal IgG2a antibody that detects CtIP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CtIP, or C-terminal binding protein interacting protein, plays a crucial role in DNA damage response and repair, particularly in breast cancer, where CtIP interacts with the breast cancer gene BRCA1. This interaction regulates the transcription of the p21 gene, which is essential for cell cycle control and apoptosis in response to DNA damage. CtIP binds to BRCA1 through BRCT repeats to modulate BRCA1′s activity, thereby influencing cellular response to genotoxic stress. The regulation of p21 transcription by the CtIP/BRCA1 complex is critical for maintaining genomic stability and preventing tumorigenesis, highlighting CtIP′s importance in cancer biology and therapeutic strategies. Anti-CtIP antibody (F-2) serves as an invaluable tool for researchers studying DNA repair mechanisms and CtIP′s role in various cellular processes.
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CtIP Antibody (F-2) References:
- CtIP tetramer assembly is required for DNA-end resection and repair. | Davies, OR., et al. 2015. Nat Struct Mol Biol. 22: 150-157. PMID: 25558984
- CtIP/Ctp1/Sae2, molecular form fit for function. | Andres, SN. and Williams, RS. 2017. DNA Repair (Amst). 56: 109-117. PMID: 28623092
- CtIP is essential for telomere replication. | Stroik, S., et al. 2019. Nucleic Acids Res. 47: 8927-8940. PMID: 31378812
- The internal region of CtIP negatively regulates DNA end resection. | Howard, SM., et al. 2020. Nucleic Acids Res. 48: 5485-5498. PMID: 32347940
- Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. | Zhang, C., et al. 2022. Mol Cell. 82: 1297-1312.e8. PMID: 35219381
- PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP. | Qiu, Z., et al. 2022. Front Cell Dev Biol. 10: 902403. PMID: 36092721
- CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis. | Oh, W., et al. 2022. Cells. 11: PMID: 36139389
- POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps. | Mann, A., et al. 2022. Mol Cell. 82: 4218-4231.e8. PMID: 36400008
- PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection. | Ceppi, I., et al. 2023. Genes Dev. 37: 119-135. PMID: 36746606
- NUDT16 regulates CtIP PARylation to dictate homologous recombination repair. | Zhang, Z., et al. 2024. Nucleic Acids Res. 52: 3761-3777. PMID: 38324469
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CtIP Antibody (F-2) | sc-28324 | 200 µg/ml | $322.00 | |||
CtIP Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-536712 | 200 µg Ab; 10 µg BP | $361.00 | |||
CtIP Antibody (F-2): m-IgGκ BP-HRP Bundle | sc-533872 | 200 µg Ab; 40 µg BP | $361.00 | |||
CtIP Antibody (F-2): m-IgG2a BP-HRP Bundle | sc-547855 | 200 µg Ab; 10 µg BP | $361.00 |