CTGF Antibody (E-5): sc-365970

CTGF Antibody (E-5) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect Connective Tissue Growth Factor (CTGF), also known as CCN2. Anti-CTGF antibody (E-5) recognizes an epitope mapped to amino acids 170-207 within an internal region of human CTGF and is effective in identifying CTGF from mouse, rat, human, equine, canine, and bovine species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CTGF is a vital member of the CCN family of immediate early proteins, involved in regulating cell proliferation, migration, and extracellular matrix production, which are critical processes for tissue development, repair, and fibrosis. Located primarily in the extracellular matrix, CTGF facilitates essential cell-matrix interactions and signaling pathways that maintain tissue homeostasis and drive fibrotic responses in various diseases. CTGF is secreted by endothelial cells, fibroblasts, smooth muscle cells, and myofibroblasts, highlighting its significant role in vascular biology and the progression of fibrotic conditions. Elevated CTGF levels are closely associated with numerous fibrotic diseases, including those affecting the kidneys, liver, and lungs, making CTGF a key target for both research and therapeutic strategies aimed at mitigating fibrosis. The extracellular localization of CTGF allows interaction with multiple receptors and growth factors, thereby influencing cellular behavior and tissue remodeling. Available in both non-conjugated and various conjugated forms such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® derivatives, CTGF (E-5) antibody offers versatile applications for diverse experimental needs. CTGF monoclonal antibody (E-5) is an essential tool for researchers exploring molecular mechanisms of CTGF in fibrosis, angiogenesis, and tissue repair, providing reliable detection and analysis of this critical growth factor in multiple biological contexts.

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CTGF Antibody (E-5) References:

1. Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro.  |  Fan, WH., et al. 2000. Eur J Cell Biol. 79: 915-23. PMID: 11152282
2. Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis.  |  Ito, Y., et al. 2001. J Am Soc Nephrol. 12: 472-484. PMID: 11181795
3. Connective tissue growth factor expression in pediatric myofibroblastic tumors.  |  Kasaragod, AB., et al. 2001. Pediatr Dev Pathol. 4: 37-45. PMID: 11200489
4. Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism.  |  Nakanishi, T., et al. 2001. Biochem Biophys Res Commun. 281: 678-81. PMID: 11237711
5. Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary.  |  Ehrchen, J., et al. 2001. J Endocrinol. 169: 87-96. PMID: 11250650
6. Expression of Nov, CYR61 and CTGF genes in human hepatocellular carcinoma.  |  Hirasaki, S., et al. 2001. Hepatol Res. 19: 294-305. PMID: 11251312

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CTGF Antibody (E-5) has 82 citations in a variety of scientific publications.

Primary antibodies like Anti-CTGF Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CTGF Antibody (E-5) Specifications

Alternate Product Name: CTGF

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 170-207

Epitope Target: CTGF

Epitope Species: human

Product Reactivity/Detection: CTGF

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 82 citations in various scientific publications

Available Conjugates/Forms for CTGF Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred CTGF antibody is CTGF Antibody (6B13): sc-101586.