CRP3 Antibody (B-4): sc-393599
- CRP3 Antibody (B-4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 82-109 within an internal region of CRP3 of human origin
- recommended for detection of CRP3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and porcine
- See CRP3 (A-5): sc-166930 for CRP3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CRP3 Antibody (B-4) for WB and IHC(P) applications. These reagents are now offered in bundles with CRP3 Antibody (B-4) (see ordering information below).
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CRP3 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects cysteine and glycine-rich protein 3 (CRP3) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CRP3 plays a crucial role in myogenic differentiation as an essential nuclear regulator, and proper function is vital for muscle development and maintenance. CRP3 features two LIM zinc-binding domains connected by short glycine-rich repeats, which are important for structural integrity and function in cellular signaling pathways. Additionally, CRP3 contains a potential nuclear localization signal that facilitates transport into the nucleus, where CRP3 can exert regulatory effects on gene expression. Notably, defects in the gene encoding CRP3 (CSRP3) can lead to dilated cardiomyopathy 1M (CMD1M), a serious condition characterized by impaired cardiac function and dilation, underscoring CRP3′s importance in cardiovascular health. Human CSRP3 is located at gene locus 11p15.1, highlighting genetic significance in the context of muscle and heart diseases. Anti-CRP3 antibody (B-4) is an invaluable tool for researchers investigating CRP3′s role in muscle biology and related pathologies.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRP3 Antibody (B-4) References:
- Synergistic up-regulation of muscle LIM protein expression in C2C12 and NIH3T3 cells by myogenin and MEF2C. | Ji, ZX., et al. 2009. Mol Genet Genomics. 281: 1-10. PMID: 18987887
- Induction of CRP3/MLP expression during vein arterialization is dependent on stretch rather than shear stress. | Campos, LC., et al. 2009. Cardiovasc Res. 83: 140-7. PMID: 19351738
- 1H, 13C, and 15N assignment of the muscular LIM protein MLP/CRP3. | Schallus, T., et al. 2007. Biomol NMR Assign. 1: 41-3. PMID: 19636821
- Baseline and postoperative C-reactive protein levels predict mortality in operable lung cancer. | Pastorino, U., et al. 2017. Eur J Cancer. 79: 90-97. PMID: 28472743
- Cyclic stretch-induced Crp3 sensitizes vascular smooth muscle cells to apoptosis during vein arterialization remodeling. | Campos, LCG., et al. 2018. Clin Sci (Lond).. PMID: 29437853
- Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. | Hernandez-Carretero, A., et al. 2018. Am J Physiol Endocrinol Metab. 315: E267-E278. PMID: 29634311
- Baseline and Postoperative C-reactive Protein Levels Predict Long-Term Survival After Lung Metastasectomy. | Pastorino, U., et al. 2019. Ann Surg Oncol. 26: 869-875. PMID: 30607764
- Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States. | Weisenfeld, D., et al. 2024. Arthritis Rheumatol. 76: 356-362. PMID: 37791989
- Cysteine and glycine-rich protein 3 (Crp3) as a critical regulator of elastolysis, inflammation, and smooth muscle cell apoptosis in abdominal aortic aneurysm development. | de Mattos, ABM., et al. 2023. Front Physiol. 14: 1252470. PMID: 38173933
- Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). | Nagulapalli, S., et al. 1995. J Immunol. 155: 4330-8. PMID: 7594592
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRP3 Antibody (B-4) | sc-393599 | 200 µg/ml | $322.00 | |||
CRP3 Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-538256 | 200 µg Ab; 10 µg BP | $361.00 | |||
CRP3 Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-535833 | 200 µg Ab; 40 µg BP | $361.00 | |||
CRP3 Antibody (B-4): m-IgG1 BP-HRP Bundle | sc-545603 | 200 µg Ab; 20 µg BP | $361.00 | |||
CRP3 (B-4) Neutralizing Peptide | sc-393599 P | 100 µg/0.5 ml | $69.00 |