CRMP-5 Antibody (F-4): sc-376921
- CRMP-5 Antibody (F-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 509-534 at the C-terminus of CRMP-5 of human origin
- recommended for detection of CRMP-5 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CRMP-5 Antibody (F-4) for WB and IHC(P) applications. These reagents are now offered in bundles with CRMP-5 Antibody (F-4) (see ordering information below).
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CRMP-5 Antibody (F-4) is a mouse monoclonal IgG2a antibody that detects CRMP-5 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CRMP-5, a member of the collapsin response mediator protein family, plays a crucial role in neuronal development and plasticity by mediating signal transduction in response to the axon guidance molecule Semaphorin 3A. CRMP-5 is predominantly located in the filopodia of growth cones during development, which is essential for the proper formation of neuronal connections. In adult neurons, CRMP-5 continues to be expressed in synapses, highlighting CRMP-5′s importance in maintaining synaptic plasticity and facilitating communication between neurons. Notably, CRMP-5 has been implicated in paraneoplastic syndromes, particularly as an autoantibody associated with small-cell lung carcinoma and thymoma, making CRMP-5 a significant target for research in neuro-oncology. Anti-CRMP-5 antibody (F-4) versatility in various applications allows researchers to explore CRMP-5′s role in both normal physiology and disease states, providing valuable insights into neuronal function and pathology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRMP-5 Antibody (F-4) | sc-376921 | 200 µg/ml | $322.00 | |||
CRMP-5 Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-538011 | 200 µg Ab; 10 µg BP | $361.00 | |||
CRMP-5 Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-535527 | 200 µg Ab; 40 µg BP | $361.00 | |||
CRMP-5 Antibody (F-4): m-IgG2a BP-HRP Bundle | sc-548183 | 200 µg Ab; 10 µg BP | $361.00 | |||
CRMP-5 (F-4) Neutralizing Peptide | sc-376921 P | 100 µg/0.5 ml | $69.00 |