CRMP-2 Antibody (E-9): sc-376739
- CRMP-2 Antibody (E-9) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 509-543 near the C-terminus of CRMP-2 of human origin
- recommended for detection of CRMP-2 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CRMP-2 Antibody (E-9) for WB and IHC(P) applications. These reagents are now offered in bundles with CRMP-2 Antibody (E-9) (see ordering information below).
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CRMP-2 Antibody (E-9) is a mouse monoclonal IgG2b light chain antibody that detects CRMP-2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CRMP-2 plays a crucial role in axonal growth and guidance, which is vital for proper neural development and function. CRMP-2 is particularly important in the context of neurodevelopmental disorders, as CRMP-2 gene is located at 8p21.2, a chromosomal region linked to schizophrenia and its associated symptoms. CRMP-2 expression is notably high during development but decreases significantly in the adult brain, although CRMP-2 remains present in areas that exhibit ongoing differentiation and plasticity. This dynamic expression pattern underscores CRMP-2′s importance in both nervous system development and potential involvement in neuropsychiatric conditions, making anti-CRMP-2 antibody (E-9) an essential tool for researchers studying these critical processes.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRMP-2 Antibody (E-9) References:
- Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2. | Brittain, JM., et al. 2012. FEBS Lett. 586: 3813-8. PMID: 23022559
- CRMP2: functional roles in neural development and therapeutic potential in neurological diseases. | Ip, JP., et al. 2014. Neuroscientist. 20: 589-98. PMID: 24402611
- Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide. | Wilson, SM. and Khanna, R. 2015. Mol Neurobiol. 51: 599-609. PMID: 24944082
- The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. | Martins-de-Souza, D., et al. 2015. Proteomics Clin Appl. 9: 817-31. PMID: 25921334
- Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau. | Hensley, K. and Kursula, P. 2016. J Alzheimers Dis. 53: 1-14. PMID: 27079722
- CRMP2-Neurofibromin Interface Drives NF1-related Pain. | Moutal, A., et al. 2018. Neuroscience. 381: 79-90. PMID: 29655575
- Induction of CRMP-2 phosphorylation by CDK5 restricts the repair of damaged optic nerve. | Chen, X., et al. 2019. J Cell Physiol. 234: 11240-11246. PMID: 30537069
- Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15. | Gomez, K., et al. 2021. Mol Brain. 14: 20. PMID: 33478555
- CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons. | Brustovetsky, T., et al. 2021. Cells. 10: PMID: 34685760
- Intranasal CRMP2-Ubc9 inhibitor regulates Na V 1.7 to alleviate trigeminal neuropathic pain. | Loya-Lopez, SI., et al. 2024. Pain. 165: 573-588. PMID: 37751532
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRMP-2 Antibody (E-9) | sc-376739 | 200 µg/ml | $322.00 | |||
CRMP-2 Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-535511 | 200 µg Ab; 40 µg BP | $361.00 | |||
CRMP-2 Antibody (E-9): m-IgG2b BP-HRP Bundle | sc-549436 | 200 µg Ab; 10 µg BP | $361.00 | |||
CRMP-2 (E-9) Neutralizing Peptide | sc-376739 P | 100 µg/0.5 ml | $69.00 |