CRIP2 Antibody (G-12): sc-166813

CRIP2 Antibody (G-12) is a mouse monoclonal IgG1 antibody that detects Cysteine-rich protein 2 (CRIP2) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRIP2 is a 208 amino acid protein characterized by two LIM zinc-binding domains linked to short glycine-rich repeats, along with a potential nuclear localization signal, which is crucial for its role in cellular processes. CRIP2 (G-12) antibody recognizes a protein that participates in the organization of multiprotein complexes, playing a significant role in cytoskeletal remodeling in the cytoplasm and facilitating smooth muscle differentiation in the nucleus. This structural versatility is essential for maintaining cellular integrity and function, particularly in tissues where smooth muscle contraction is vital, such as the heart, where CRIP2 expression is most abundant. The human CRIP2 gene is located on chromosome 14q32.33, highlighting its genetic significance. With its broad tissue expression and critical functions, anti-CRIP2 antibody (G-12) is an invaluable tool for researchers studying muscle differentiation and cytoskeletal dynamics.

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CRIP2 Antibody (G-12) References:

1. ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.  |  Tanabe, C., et al. 2010. Biochem Biophys Res Commun. 396: 927-32. PMID: 20460109
2. Unlocking the Rosetta Stone enigma for nasopharyngeal carcinoma: genetics, viral infection, and epidemiological factors.  |  Lung, ML. 2012. Semin Cancer Biol. 22: 77-8. PMID: 22266061
3. Identification of potentially relevant genes for myocardial infarction using RNA sequencing data analysis.  |  Zhao, Q., et al. 2018. Exp Ther Med. 15: 1456-1464. PMID: 29399125
4. HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.  |  Zhou, L., et al. 2018. Nat Commun. 9: 1480. PMID: 29662084
5. Identification of LBX2 as a novel causal gene of atrial septal defect.  |  Wang, J., et al. 2018. Int J Cardiol. 265: 188-194. PMID: 29669692
6. Genome-wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy.  |  Wang, F., et al. 2021. FEBS Lett. 595: 2271-2289. PMID: 34328660
7. Screening and verification of potential gene targets in esophageal carcinoma by bioinformatics analysis and immunohistochemistry.  |  Wen, P., et al. 2022. Ann Transl Med. 10: 70. PMID: 35282073
8. Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.  |  Hulikova, A., et al. 2022. Basic Res Cardiol. 117: 17. PMID: 35357563
9. Computer-Aided Imaging Analysis of Probe-Based Confocal Laser Endomicroscopy With Molecular Labeling and Gene Expression Identifies Markers of Response to Biological Therapy in IBD Patients: The Endo-Omics Study.  |  Iacucci, M., et al. 2022. Inflamm Bowel Dis.. PMID: 36378498
10. Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation.  |  Verdejo-Torres, O., et al. 2024. bioRxiv.. PMID: 38746126

The preferred CRIP2 antibody is CRIP2 Antibody (C-2): sc-271659.