CRIP2 Antibody (C-2): sc-271659

CRIP2 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CRIP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRIP2 Antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cysteine-rich protein 2 (CRIP2) is a 208 amino acid protein characterized by two LIM zinc-binding domains that are linked to short glycine-rich repeats, as well as a potential nuclear localization signal, which is crucial for cellular processes. The presence of these LIM domains allows CRIP2 to interact with other proteins, facilitating the assembly of multiprotein complexes that play significant roles in cytoskeletal remodeling in the cytoplasm and promoting smooth muscle differentiation in the nucleus. The widespread expression of CRIP2 across various tissues, particularly in the heart, underscores its importance in cardiovascular health and development. The human CRIP2 gene is located on chromosome 14q32.33, highlighting its genetic significance in relation to various physiological and pathological conditions.

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CRIP2 Antibody (C-2) References:

1. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle.  |  Huber, A., et al. 2000. J Biol Chem. 275: 5504-11. PMID: 10681529
2. Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.  |  Chang, DF., et al. 2003. Dev Cell. 4: 107-18. PMID: 12530967
3. Identification of a CArG-independent region of the cysteine-rich protein 2 promoter that directs expression in the developing vasculature.  |  Chang, YF., et al. 2003. Am J Physiol Heart Circ Physiol. 285: H1675-83. PMID: 12791591
4. Increased neointima formation in cysteine-rich protein 2-deficient mice in response to vascular injury.  |  Wei, J., et al. 2005. Circ Res. 97: 1323-31. PMID: 16269651
5. Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.  |  Schmidtko, A., et al. 2008. J Neurosci. 28: 1320-30. PMID: 18256252
6. Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.  |  Lin, DW., et al. 2008. J Biol Chem. 283: 15003-14. PMID: 18387947
7. The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.  |  Lo, PH., et al. 2012. Cancer Lett. 316: 39-45. PMID: 22154084
8. MiR-449a promotes breast cancer progression by targeting CRIP2.  |  Shi, W., et al. 2016. Oncotarget. 7: 18906-18. PMID: 26934316
9. APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.  |  Chen, L., et al. 2021. Angew Chem Int Ed Engl. 60: 25346-25355. PMID: 34550632
10. Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells.  |  Li, F., et al. 2021. Biochem Biophys Res Commun. 584: 73-79. PMID: 34773852
11. Cloning of CRP2, a novel member of the cysteine-rich protein family with two repeats of an unusual LIM/double zinc-finger motif.  |  Okano, I., et al. 1993. FEBS Lett. 333: 51-5. PMID: 8224170
12. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3.  |  Karim, MA., et al. 1996. Genomics. 31: 167-76. PMID: 8824798

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CRIP2 Antibody (C-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CRIP2 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CRIP2 Antibody (C-2) Specifications

Alternate Product Name: CRIP2

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 69-121

Epitope Target: CRIP2

Epitope Species: human

Product Reactivity/Detection: CRIP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CRIP2 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin