creatine kinase-B Antibody (G-6): sc-374072
- creatine kinase-B Antibody (G-6) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-30 at the N-terminus of creatine kinase-B of human origin
- recommended for detection of creatine kinase-B chain of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for creatine kinase-B Antibody (G-6) for WB applications. This reagent is now offered in a bundle with creatine kinase-B Antibody (G-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Creatine kinase-B Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects creatine kinase-B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Creatine kinase-B, also known as CK-B or BCK, is a 381 amino acid isoform specifically expressed in brain tissue, playing a crucial role in cellular energy metabolism. Anti-creatine kinase-B antibody (G-6) efficiently detects this essential protein that maintains ATP levels in neurons, which is vital for proper synaptic function and overall brain health. Creatine kinase-B′s cytoplasmic localization enables efficient ATP supply to areas of high energy demand, particularly during intense neuronal activity. Dysregulation of creatine kinase-B has been implicated in various neurological disorders, highlighting its importance in both normal physiology and disease states. Creatine kinase-B (G-6) antibody serves as an invaluable tool for researchers studying energy metabolism in the brain and its implications in neurodegenerative diseases, providing insights into the intricate balance of energy homeostasis in neuronal cells.
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creatine kinase-B Antibody (G-6) References:
- Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. | Jost, CR., et al. 2002. Eur J Neurosci. 15: 1692-706. PMID: 12059977
- Creatine kinase B deficient neurons exhibit an increased fraction of motile mitochondria. | Kuiper, JW., et al. 2008. BMC Neurosci. 9: 73. PMID: 18662381
- Regulation of T cell development and activation by creatine kinase B. | Zhang, Y., et al. 2009. PLoS One. 4: e5000. PMID: 19337362
- Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis. | Li, XH., et al. 2013. Int J Biochem Cell Biol. 45: 979-86. PMID: 23416112
- Radioimmunoassay of creatine kinase-B isoenzyme in human sera: results in patients with acute myocardial infarction. | Willerson, JT., et al. 1977. Proc Natl Acad Sci U S A. 74: 1711-5. PMID: 266211
- Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci. | Kaye, FJ., et al. 1987. J Clin Invest. 79: 1412-20. PMID: 2883200
- Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71. | Sandebring-Matton, A., et al. 2021. Front Aging Neurosci. 13: 735334. PMID: 34867272
- Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation. | Renzi, G., et al. 2025. Mol Metab. 92: 102082. PMID: 39675471
- Creatine kinase-B mRNA levels in brain regions from male and female rats. | Ilyin, SE., et al. 1996. Brain Res Mol Brain Res. 41: 50-6. PMID: 8883933
- Activation of creatine kinase-B and phospholamban gene expression in transformed latissimus dorsi muscle: evaluation of mRNA by polymerase chain reaction. | Alam, M., et al. 1996. J Mol Cell Cardiol. 28: 1901-10. PMID: 8899549
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
creatine kinase-B Antibody (G-6) | sc-374072 | 200 µg/ml | $316.00 | |||
creatine kinase-B Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-522608 | 200 µg Ab, 40 µg BP | $354.00 | |||
creatine kinase-B (G-6) Neutralizing Peptide | sc-374072 P | 100 µg/0.5 ml | $68.00 |