CPTI-M Antibody (D-8): sc-515709

CPTI-M Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects carnitine palmitoyltransferase I (CPTI) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CPTI plays a crucial role in the mitochondrial β-oxidation of long-chain fatty acids, serving as the first enzyme in the transport process that moves these fatty acids from the cytoplasm into the mitochondria, which is essential for energy production. The protein exists in two isoforms, CPTIA and CPTIB, with the muscle type (CPTIB) being predominantly expressed in heart and skeletal muscle tissues, highlighting its importance in energy metabolism during physical activity. Notably, CPTI is regulated by malonyl-coenzyme A, which inhibits its activity and thus plays a significant role in controlling fatty acid oxidation based on the cell′s energy needs. The integrity of the mitochondrial membrane is vital for CPTI′s function, as CPTI requires a proper membrane environment to catalyze reactions effectively. Anti-CPTI antibody (D-8) is an invaluable tool for researchers studying metabolic disorders, cardiac function, and the regulation of fatty acid metabolism, providing insights into the physiological and pathological roles of CPTI in human health.

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CPTI-M Antibody (D-8) References:

1. Effect of cpTi surface roughness on human bone marrow cell attachment, proliferation, and differentiation.  |  Rosa, AL. and Beloti, MM. 2003. Braz Dent J. 14: 16-21. PMID: 12656459
2. Efficacy of transgenic rice expressing Cry1Ac and CpTI against the rice leaffolder, Cnaphalocrocis medinalis (Guenée).  |  Han, L., et al. 2007. J Invertebr Pathol. 96: 71-9. PMID: 17445827
3. In vitro cytotoxicity of dental alloys and cpTi obtained by casting.  |  Faria, AC., et al. 2008. J Biomed Mater Res B Appl Biomater. 85: 504-8. PMID: 18076091
4. Influence of pH on the tribocorrosion behavior of CpTi in the oral environment: synergistic interactions of wear and corrosion.  |  Mathew, MT., et al. 2012. J Biomed Mater Res B Appl Biomater. 100: 1662-71. PMID: 22707174
5. Evaluation of real-time PCR detection methods for detecting rice products contaminated by rice genetically modified with a CpTI-KDEL-T-nos transgenic construct.  |  Nakamura, K., et al. 2013. Food Chem. 141: 2618-24. PMID: 23871003
6. Electrochemical behavior of bioactive coatings on cp-Ti surface for dental application.  |  Marques, ID., et al. 2015. Corros Sci. 100: 133-146. PMID: 26834277
7. Impact of transgenic Cry1Ac + CpTI cotton on diversity and dynamics of rhizosphere bacterial community of different root environments.  |  Li, P., et al. 2018. Sci Total Environ. 637-638: 233-243. PMID: 29751306
8. Design and performance evaluation of additively manufactured composite lattice structures of commercially pure Ti (CP-Ti).  |  Xu, W., et al. 2021. Bioact Mater. 6: 1215-1222. PMID: 33210019
9. Characterization of the malonyl-CoA-sensitive carnitine palmitoyltransferase (CPTo) of a rat heart mitochondrial particle. Evidence that the catalytic unit is CPTi.  |  Kerner, J., et al. 1994. J Biol Chem. 269: 8209-19. PMID: 8132545

The preferred CPTI antibody is CPTI Antibody (E-7): sc-393070.