CPSF7 Antibody (A-9): sc-393880
- CPSF7 Antibody (A-9) is a mouse monoclonal IgG1 κ CPSF7 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 185-237 mapping within an internal region of CPSF7 of human origin
- CPSF7 Antibody (A-9) is recommended for detection of CPSF7 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-CPSF7 Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CPSF7 Antibody (A-9) for WB applications. These reagents are now offered in bundles with CPSF7 Antibody (A-9) (see ordering information below).
CPSF7 Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects CPSF7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CPSF7 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CPSF7 protein, also known as cleavage and polyadenylation specificity factor 7, plays a crucial role in the processing of 3′ ends of eukaryotic mRNAs, which is essential for mRNA stability and translation efficiency. CPSF7 is involved in the endonucleolytic cleavage and subsequent polyadenylation of pre-mRNA, a process vital for mRNA maturation and gene expression regulation. CPSF7 is a 471 amino acid nuclear protein that belongs to the RNA recognition motif CPSF6/7 family and is encoded by a gene located on human chromosome 11q12.2, a region associated with several genetic disorders. Alternative splicing events result in two isoforms of CPSF7, which may have distinct functional roles in mRNA processing. Understanding CPSF7 function and interactions is important for elucidating gene regulation mechanisms and potential implications in various diseases linked to mRNA processing defects.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CPSF7 Antibody (A-9) References:
- Hereditary angioedema. Long-term follow-up of 88 patients. Experience of the Argentine Allergy and Immunology Institute. | Fabiani, JE., et al. 2000. Allergol Immunopathol (Madr). 28: 267-71. PMID: 11270087
- A history of poly A sequences: from formation to factors to function. | Edmonds, M. 2002. Prog Nucleic Acid Res Mol Biol. 71: 285-389. PMID: 12102557
- Smith-Lemli-Opitz syndrome and the DHCR7 gene. | Jira, PE., et al. 2003. Ann Hum Genet. 67: 269-80. PMID: 12914579
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
- The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease. | Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
- Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). | Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
- An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome. | Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783
- Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I. | Jenny, A., et al. 1996. Science. 274: 1514-7. PMID: 8929409
- Characterization of a Drosophila homologue of the 160-kDa subunit of the cleavage and polyadenylation specificity factor CPSF. | Salinas, CA., et al. 1998. Mol Gen Genet. 257: 672-80. PMID: 9604891
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CPSF7 Antibody (A-9) | sc-393880 | 200 µg/ml | $316.00 | |||
CPSF7 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-530618 | 200 µg Ab; 10 µg BP | $354.00 | |||
CPSF7 Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-524132 | 200 µg Ab, 40 µg BP | $354.00 | |||
CPSF7 Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-544165 | 200 µg Ab; 20 µg BP | $354.00 | |||
CPSF7 Antibody (A-9) AC | sc-393880 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CPSF7 Antibody (A-9) HRP | sc-393880 HRP | 200 µg/ml | $316.00 | |||
CPSF7 Antibody (A-9) FITC | sc-393880 FITC | 200 µg/ml | $330.00 | |||
CPSF7 Antibody (A-9) PE | sc-393880 PE | 200 µg/ml | $343.00 | |||
CPSF7 Antibody (A-9) Alexa Fluor® 488 | sc-393880 AF488 | 200 µg/ml | $357.00 | |||
CPSF7 Antibody (A-9) Alexa Fluor® 546 | sc-393880 AF546 | 200 µg/ml | $357.00 | |||
CPSF7 Antibody (A-9) Alexa Fluor® 594 | sc-393880 AF594 | 200 µg/ml | $357.00 | |||
CPSF7 Antibody (A-9) Alexa Fluor® 647 | sc-393880 AF647 | 200 µg/ml | $357.00 | |||
CPSF7 Antibody (A-9) Alexa Fluor® 680 | sc-393880 AF680 | 200 µg/ml | $357.00 | |||
CPSF7 Antibody (A-9) Alexa Fluor® 790 | sc-393880 AF790 | 200 µg/ml | $357.00 |