CPOX Antibody (B-9): sc-393388

CPOX Antibody (B-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects CPOX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CPOX Antibody (B-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CPOX (coproporphyrinogen III oxidase) is a crucial 454 amino acid mitochondrial enzyme located in the inner membrane space of erythrocytes, where CPOX plays a vital role in heme biosynthesis by catalyzing the conversion of coproporphyrinogen III to protoporphyrinogen IX, the sixth step in the heme production pathway. This enzymatic function is essential for the synthesis of heme, a critical component of hemoglobin and various other heme-containing proteins that are vital for oxygen transport and cellular respiration. Mutations in the gene encoding CPOX can lead to coproporphyria, an autosomal dominant disorder characterized by skin photosensitivity and neurological symptoms, often manifesting as painful attacks. Individuals with coproporphyria typically excrete elevated levels of coproporphyrinogen III in their urine and feces, and the enzymatic activity of CPOX is significantly reduced, resulting in decreased heme synthesis. While there is currently no cure for coproporphyria, management strategies focus on dietary modifications and avoiding certain medications and alcohol to alleviate symptoms.

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CPOX Antibody (B-9) References:

1. The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria.  |  Susa, S., et al. 2003. Tohoku J Exp Med. 200: 39-45. PMID: 12862310
2. Investigation of the catalytic and structural roles of conserved histidines of human coproporphyrinogen oxidase using site-directed mutagenesis.  |  Gitter, SJ., et al. 2007. Med Sci Monit. 13: BR1-10. PMID: 17179900
3. A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria.  |  Lamoril, J., et al. 1995. Hum Mol Genet. 4: 275-8. PMID: 7757079
4. Coproporphyrinogen oxidase: gene organization and description of a mutation leading to exon 6 skipping.  |  Delfau-Larue, MH., et al. 1994. Hum Mol Genet. 3: 1325-30. PMID: 7987309
5. Homozygous hereditary coproporphyria caused by an arginine to tryptophane substitution in coproporphyrinogen oxidase and common intragenic polymorphisms.  |  Martasek, P., et al. 1994. Hum Mol Genet. 3: 477-80. PMID: 8012360
6. Molecular cloning, sequencing and expression of cDNA encoding human coproporphyrinogen oxidase.  |  Taketani, S., et al. 1994. Biochim Biophys Acta. 1183: 547-9. PMID: 8286403
7. Three novel mutations in the coproporphyrinogen oxidase gene.  |  Lamoril, J., et al. 1997. Hum Mutat. 9: 78-80. PMID: 8990017
8. A novel missense mutation in exon 4 of the human coproporphyrinogen oxidase gene in two patients with hereditary coproporphyria.  |  Daimon, M., et al. 1997. Hum Genet. 99: 199-201. PMID: 9048920

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CPOX Antibody (B-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-CPOX Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CPOX Antibody (B-9) Specifications

Alternate Product Name: CPOX

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 155-454

Epitope Target: CPOX

Epitope Species: human

Product Reactivity/Detection: CPOX

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for CPOX Antibody (B-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin