CPOX Inhibitors
CPOX inhibitors, short for coproporphyrinogen oxidase inhibitors, belong to a distinct chemical class crucial in the regulation of heme biosynthesis, a fundamental cellular process. These inhibitors specifically target the enzyme coproporphyrinogen oxidase (CPOX), an essential component of the heme synthesis pathway. Heme, a vital cofactor, plays a pivotal role in various biological functions, such as oxygen transport, electron transfer, and enzymatic catalysis. CPOX, positioned at the branch point of heme biosynthesis, catalyzes the conversion of coproporphyrinogen III to protoporphyrinogen IX, a critical intermediate in heme production.
CPOX inhibitors involves binding to the active site of the enzyme, impeding its catalytic activity. By disrupting this key step in the heme biosynthetic pathway, CPOX inhibitors modulate cellular heme levels, influencing downstream processes that rely on this essential cofactor. The structural diversity among CPOX inhibitors allows for selective targeting of the enzyme, offering researchers valuable tools for investigating the intricacies of heme regulation in cellular physiology
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Succinylacetone | 51568-18-4 | sc-212963 sc-212963B | 10 mg 100 mg | $336.00 $418.00 | ||
Succinylacetone inhibits CPOX by binding to its active site, preventing the conversion of coproporphyrinogen III to protoporphyrinogen IX. | ||||||
Iron(III) chloride | 7705-08-0 | sc-215192 sc-215192A sc-215192B | 10 g 100 g 500 g | $41.00 $46.00 $87.00 | ||
Iron(III) chloride can inhibit CPOX indirectly by creating an iron overload condition that disrupts the heme synthesis pathway. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Protoporphyrin-9 can reduce CPOX activity by competitive inhibition via its structural similarity to protoporphyrinogen IX. | ||||||
Aluminum chloride anhydrous | 7446-70-0 | sc-214528 sc-214528B sc-214528A | 250 g 500 g 1 kg | $94.00 $99.00 $136.00 | ||
Aluminum chloride can disrupt the heme synthesis pathway, indirectly inhibiting CPOX. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper (II) Sulfate can inhibit CPOX indirectly by creating a copper overload condition that disrupts the heme synthesis pathway. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium Chloride can inhibit CPOX directly by binding to its active site. | ||||||
Gallium Nitrate | 69365-72-6 | sc-358673 sc-358673A | 1 g 5 g | $20.00 $82.00 | ||
Gallium Nitrate can inhibit CPOX indirectly via disruption of the heme synthesis pathway. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese(II) Chloride can disrupt CPOX activity indirectly by influencing the heme biosynthesis pathway. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $40.00 | 8 | |
Dicoumarol can inhibit CPOX indirectly by disrupting the heme synthesis pathway via its anticoagulant properties. | ||||||