CPA2 Antibody (B-8): sc-393700

CPA2 Antibody (B-8) is a mouse monoclonal IgG2b antibody that detects CPA2 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CPA2, or Carboxypeptidase A2, is a 417 amino acid zinc-binding secreted protein that plays a crucial role in protein digestion and degradation by catalyzing the release of C-terminal amino acids from various proteins. This enzyme is particularly important due to its ability to preferentially cleave bulkier C-terminal residues, which distinguishes CPA2 from its closely related counterpart, CPA1. CPA2 expression has been identified in several tissues, including the pancreas, brain, lung, and testis, highlighting its diverse physiological roles. Notably, CPA2 is synthesized as an inactive precursor that undergoes post-translational modification, specifically the cleavage of a characteristic propeptide at the amino-terminus, which is essential for activation and subsequent enzymatic function. Anti-CPA2 antibody (B-8) is an invaluable tool for researchers studying the intricate mechanisms of protein metabolism and the specific roles of carboxypeptidases in various biological processes.

The preferred CPA2 antibody is CPA2 Antibody (B-5): sc-393547.