Cox-1 Antibody (11): sc-19998
- Cox-1 Antibody (11) is a mouse monoclonal IgG2b κ Cox-1 antibody, cited in 60 publications, provided at 200 µg/ml
- raised against Cox-1 purified from ovine seminal vesicles
- Cox-1 Antibody (11) is recommended for detection of Cyclooxygenase-1 of mouse, rat, human and ovine origin by WB, IP, IF, IHC(P) and FCM; may cross-react with human recombinant, human platelet, rat and mouse COX-1 and slightly (5%) with ovine COX-2; non cross-reactive with human or mouse COX-2
- Anti-Cox-1 Antibody (11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cox-1 Antibody (11) for WB and IHC(P) applications. These reagents are now offered in bundles with Cox-1 Antibody (11) (see ordering information below).
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Cox-1 Antibody (11) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect Cyclooxygenase-1 (COX-1), also known as PTGS1 or prostaglandin-endoperoxide synthase 1, across multiple species including mouse, rat, human, and ovine origins. COX-1 mouse monoclonal antibody (11) is raised against COX-1 purified from ovine seminal vesicles, ensuring robust and specific binding to its target epitope. COX-1 is a critical enzyme involved in the biosynthesis of prostaglandins, which are essential lipid compounds that regulate a wide array of physiological processes such as inflammation, blood flow, and the formation of blood clots. By catalyzing the conversion of arachidonic acid to prostaglandin H2 (PGH2), COX-1 plays a fundamental housekeeping role in maintaining normal cellular functions. COX-1 monoclonal antibody (11) is versatile in its applications, performing reliably in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Additionally, COX-1 monoclonal antibody (11) is available in various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, to accommodate different experimental requirements. COX-1 monoclonal antibody (11) enables researchers to investigate the expression, localization, and functional dynamics of COX-1, shedding light on its role in physiological and pathological processes, and facilitating the discovery of novel insights into lipid signaling and inflammation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cox-1 Antibody (11) References:
- Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. | O'Neill, GP., et al. 1994. Mol Pharmacol. 45: 245-54. PMID: 8114674
- Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. | O'Neill, GP. and Ford-Hutchinson, AW. 1993. FEBS Lett. 330: 156-60. PMID: 8365485
- Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. | Morham, SG., et al. 1995. Cell. 83: 473-82. PMID: 8521477
- Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. | Langenbach, R., et al. 1995. Cell. 83: 483-92. PMID: 8521478
- Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. | Tsujii, M. and DuBois, RN. 1995. Cell. 83: 493-501. PMID: 8521479
- Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. | Adams, J., et al. 1996. J Neurochem. 66: 6-13. PMID: 8522990
- Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on PGE2 production by articular chondrocytes does not involve PLA2 stimulation. | Berenbaum, F., et al. 1996. Exp Cell Res. 222: 379-84. PMID: 8598226
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cox-1 Antibody (11) | sc-19998 | 200 µg/ml | $316.00 | |||
Cox-1 Antibody (11): m-IgG Fc BP-HRP Bundle | sc-528346 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cox-1 Antibody (11): m-IgGκ BP-HRP Bundle | sc-520700 | 200 µg Ab, 40 µg BP | $354.00 | |||
Cox-1 Antibody (11): m-IgG2b BP-HRP Bundle | sc-550031 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cox-1 Antibody (11) AC | sc-19998 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Cox-1 Antibody (11) HRP | sc-19998 HRP | 200 µg/ml | $316.00 | |||
Cox-1 Antibody (11) FITC | sc-19998 FITC | 200 µg/ml | $330.00 | |||
Cox-1 Antibody (11) PE | sc-19998 PE | 200 µg/ml | $343.00 | |||
Cox-1 Antibody (11) Alexa Fluor® 488 | sc-19998 AF488 | 200 µg/ml | $357.00 | |||
Cox-1 Antibody (11) Alexa Fluor® 546 | sc-19998 AF546 | 200 µg/ml | $357.00 | |||
Cox-1 Antibody (11) Alexa Fluor® 594 | sc-19998 AF594 | 200 µg/ml | $357.00 | |||
Cox-1 Antibody (11) Alexa Fluor® 647 | sc-19998 AF647 | 200 µg/ml | $357.00 | |||
Cox-1 Antibody (11) Alexa Fluor® 680 | sc-19998 AF680 | 200 µg/ml | $357.00 | |||
Cox-1 Antibody (11) Alexa Fluor® 790 | sc-19998 AF790 | 200 µg/ml | $357.00 |