copine 3 Antibody (C-7): sc-390143
- copine 3 Antibody (C-7) is a mouse monoclonal IgG1 κ copine 3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 151-189 within an internal region of copine 3 of human origin
- copine 3 Antibody (C-7) is recommended for detection of copine 3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-copine 3 Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for copine 3 Antibody (C-7) for WB applications. These reagents are now offered in bundles with copine 3 Antibody (C-7) (see ordering information below).
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Copine 3 Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects copine 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-copine 3 antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Copine 3, also known as CPNE3, CPN3, or COPN3, belongs to the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins that play crucial roles in signal transduction and membrane trafficking. Copine 3 primarily resides in the cytosol as a monomer and undergoes a conformational change upon calcium binding, allowing interaction with cellular membranes. Copine 3′s ability to bind phospholipids in a calcium-dependent manner is essential for membrane trafficking function, which supports various cellular processes, including vesicle transport and signal transduction pathways. Copine 3 contains two N-terminal C2 domains and one C-terminal von Willebrand factor A domain, contributing to structural integrity and functional versatility. Moreover, copine 3 may possess intrinsic kinase activity, distinguishing this protein from other copine family members and suggesting potential roles in cellular signaling mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
copine 3 Antibody (C-7) References:
- Characterization of human copine III as a phosphoprotein with associated kinase activity. | Caudell, EG., et al. 2000. Biochemistry. 39: 13034-43. PMID: 11041869
- Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein. | Tomsig, JL. and Creutz, CE. 2000. Biochemistry. 39: 16163-75. PMID: 11123945
- Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins. | Tomsig, JL. and Creutz, CE. 2002. Cell Mol Life Sci. 59: 1467-77. PMID: 12440769
- Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. | Tomsig, JL., et al. 2003. J Biol Chem. 278: 10048-54. PMID: 12522145
- Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils. | Cowland, JB., et al. 2003. J Leukoc Biol. 74: 379-88. PMID: 12949241
- Multiple loci identified in a genome-wide association study of prostate cancer. | Thomas, G., et al. 2008. Nat Genet. 40: 310-5. PMID: 18264096
- The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. | Creutz, CE., et al. 1998. J Biol Chem. 273: 1393-402. PMID: 9430674
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
copine 3 Antibody (C-7) | sc-390143 | 200 µg/ml | $316.00 | |||
copine 3 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-530078 | 200 µg Ab; 10 µg BP | $354.00 | |||
copine 3 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-523423 | 200 µg Ab, 40 µg BP | $354.00 | |||
copine 3 Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-543858 | 200 µg Ab; 20 µg BP | $354.00 | |||
copine 3 Antibody (C-7) AC | sc-390143 AC | 500 µg/ml, 25% agarose | $416.00 | |||
copine 3 Antibody (C-7) HRP | sc-390143 HRP | 200 µg/ml | $316.00 | |||
copine 3 Antibody (C-7) FITC | sc-390143 FITC | 200 µg/ml | $330.00 | |||
copine 3 Antibody (C-7) PE | sc-390143 PE | 200 µg/ml | $343.00 | |||
copine 3 Antibody (C-7) Alexa Fluor® 488 | sc-390143 AF488 | 200 µg/ml | $357.00 | |||
copine 3 Antibody (C-7) Alexa Fluor® 546 | sc-390143 AF546 | 200 µg/ml | $357.00 | |||
copine 3 Antibody (C-7) Alexa Fluor® 594 | sc-390143 AF594 | 200 µg/ml | $357.00 | |||
copine 3 Antibody (C-7) Alexa Fluor® 647 | sc-390143 AF647 | 200 µg/ml | $357.00 | |||
copine 3 Antibody (C-7) Alexa Fluor® 680 | sc-390143 AF680 | 200 µg/ml | $357.00 | |||
copine 3 Antibody (C-7) Alexa Fluor® 790 | sc-390143 AF790 | 200 µg/ml | $357.00 | |||
copine 3 (C-7) Neutralizing Peptide | sc-390143 P | 100 µg/0.5 ml | $68.00 |