copine 1/3 Antibody (A-7): sc-393050

Copine 1/3 Antibody (A-7) is a mouse monoclonal IgG2a antibody that detects copine 1/3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Copine 1, also known as CPNE1, CPN1, or COPN1, is a member of the copine family, which consists of evolutionarily conserved, calcium-dependent membrane-binding proteins that play crucial roles in signal transduction and membrane trafficking. Copine 1 is characterized by its unique structure, featuring two N-terminal C2 domains and a C-terminal von Willebrand factor A (VWFA) domain, which is essential for function. The VWFA domain of copine 1 facilitates direct interactions with the ubiquitin-conjugating enzyme UBC12, thereby influencing the regulation of tumor necrosis factor alpha (TNFα) signaling pathways. This interaction underscores copine 1′s significance in cellular signaling processes and potential implications in various physiological and pathological conditions. Copine 3, also known as CPNE3, CPN3, or COPN3, shares a similar structural composition with copine 1, containing two N-terminal C2 domains and one C-terminal VWFA domain, and is ubiquitously expressed. Notably, copine 3 may exhibit intrinsic kinase activity, distinguishing copine 3 from other copine family members and highlighting the diverse functional roles these proteins play in cellular contexts.

The preferred copine 3 antibody is copine 3 Antibody (C-7): sc-390143.