COL5A1/2 Antibody (6F206): sc-70867

COL5A1/2 Antibody (6F206) is a mouse monoclonal IgG2a antibody that detects COL5A1/2 protein of human, canine, bovine, and porcine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). COL5A1/2 (6F206) antibody is available as the non-conjugated form. COL5A1/2 protein is a crucial component of collagen type V, which plays a significant role in the structural integrity and function of various connective tissues, including tendons, ligaments, and cartilage. COL5A1/2 is primarily located in the extracellular matrix, where COL5A1/2 contributes to the formation of a stable and resilient network that supports tissue architecture. Collagen type V is particularly important during the early stages of collagen fibril formation, as collagen type V regulates the assembly and organization of collagen fibers, ensuring proper tensile strength and elasticity in tissues. Additionally, mutations or deficiencies in COL5A1/2 can lead to connective tissue disorders, such as Ehlers-Danlos syndrome, highlighting COL5A1/2′s importance in maintaining overall tissue health and function. With proven detection capabilities across multiple species, anti-COL5A1/2 antibody (6F206) serves as an invaluable tool for researchers investigating the roles of collagen in health and disease.

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COL5A1/2 Antibody (6F206) References:

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2. Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.  |  Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
3. The Role of COL5A2 in Patients With Muscle-Invasive Bladder Cancer: A Bioinformatics Analysis of Public Datasets Involving 787 Subjects and 29 Cell Lines.  |  Meng, XY., et al. 2018. Front Oncol. 8: 659. PMID: 30697528
4. COL5A2 as a potential clinical biomarker for gastric cancer and renal metastasis.  |  Ding, YL., et al. 2021. Medicine (Baltimore). 100: e24561. PMID: 33607786
5. COL5A1 Variants Cause Aortic Dissection by Activating TGF-β-Signaling Pathway.  |  Chen, P., et al. 2021. J Am Heart Assoc. 10: e019276. PMID: 34041919
6. Independent COL5A1 Variants in Cats with Ehlers-Danlos Syndrome.  |  Kiener, S., et al. 2022. Genes (Basel). 13: PMID: 35627182
7. ENTPD1-AS1-miR-144-3p-mediated high expression of COL5A2 correlates with poor prognosis and macrophage infiltration in gastric cancer.  |  Yuan, HM., et al. 2023. World J Gastrointest Oncol. 15: 1182-1199. PMID: 37546560
8. Integrated analyses reveal the diagnostic and predictive values of COL5A2 and association with immune environment in Crohn's disease.  |  Zhong, T., et al. 2024. Genes Immun. 25: 209-218. PMID: 38789829
9. COL5A1 overexpression correlates with poor prognosis in human cervical cancer.  |  Duan, X., et al. 2024. Int J Biol Markers. 39: 265-273. PMID: 39043220
10. Cell adhesion to collagenous matrices.  |  McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
11. Versatile collagens in invertebrates.  |  Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
12. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

The preferred COL5A1 antibody is COL5A1 Antibody (C-5): sc-166155.