COL5A1/2 Antibody (006-01): sc-59818
- COL5A1/2 Antibody (006-01) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against acid digested pepsin soluble Collagen Type V of canine origin
- recommended for detection of Collagen α1 Type V and Collagen α2 Type V of human, canine, bovine and porcine origin by WB and IF; non cross-reactive with Collagen Types I, III, and VI or with other connective tissue proteins such as Laminin, Fibronectin and elastin
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COL5A1/2 Antibody (006-01). This work is in progress.
COL5A1/2 Antibody (006-01) is a mouse monoclonal IgG2a antibody that detects COL5A1/2 in human, canine, bovine, and porcine samples through applications such as western blotting (WB) and immunofluorescence (IF). COL5A1/2 is a crucial component of the extracellular matrix, primarily found in connective tissues, where COL5A1/2 plays a significant role in providing structural support and tensile strength. COL5A1/2 is essential for the formation of collagen fibrils, which are vital for the integrity and resilience of tissues such as skin, tendons, and ligaments. Proper assembly and function of COL5A1/2 are critical for maintaining tissue architecture and facilitating cell adhesion, which is important for normal physiological processes. Additionally, COL5A1/2 undergoes various post-translational modifications, including glycosylation, which can influence stability and interaction with other extracellular matrix components. These modifications are important as they can affect COL5A1/2′s functionality and role in tissue repair and regeneration. Anti-COL5A1/2 antibody (006-01) is an invaluable tool for researchers studying collagen-related disorders and the dynamics of extracellular matrix remodeling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COL5A1/2 Antibody (006-01) References:
- Clinical and molecular characterization of 40 patients with classic Ehlers-Danlos syndrome: identification of 18 COL5A1 and 2 COL5A2 novel mutations. | Ritelli, M., et al. 2013. Orphanet J Rare Dis. 8: 58. PMID: 23587214
- Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis. | Pabalan, N., et al. 2018. Sports Med Open. 4: 46. PMID: 30350114
- Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma. | Chen, HC., et al. 2019. J Oral Pathol Med. 48: 468-476. PMID: 30972812
- Overexpressed COL5A1 is correlated with tumor progression, paclitaxel resistance, and tumor-infiltrating immune cells in ovarian cancer. | Zhang, J., et al. 2021. J Cell Physiol. 236: 6907-6919. PMID: 33655494
- NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1. | Zhang, Y., et al. 2021. Signal Transduct Target Ther. 6: 173. PMID: 33941767
- lncRNA BZRAP1-AS1 alleviates rheumatoid arthritis by regulating miR-1286/COL5A2 axis. | Zhu, J., et al. 2022. Immun Inflamm Dis. 10: 163-174. PMID: 34766472
- Up-regulation of collagen type V alpha 2 (COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial-mesenchymal transition (EMT). | Jin, Y., et al. 2023. Open Med (Wars). 18: 20220593. PMID: 36712590
- LINC00173 blocks GATA6-mediated transcription of COL5A1 to affect malignant development of oral squamous cell carcinoma. | Dong, C., et al. 2023. J Oral Pathol Med. 52: 493-503. PMID: 36856154
- COL5A2 is a prognostic-related biomarker and correlated with immune infiltrates in gastric cancer based on transcriptomics and single-cell RNA sequencing. | Chen, M., et al. 2023. BMC Med Genomics. 16: 220. PMID: 37723519
- COL5A1 promotes triple-negative breast cancer progression by activating tumor cell-macrophage crosstalk. | Chen, X., et al. 2024. Oncogene. 43: 1742-1756. PMID: 38609499
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COL5A1/2 Antibody (006-01) | sc-59818 | 100 µg/ml | $316.00 |