COL4A3 Antibody (1042): sc-52317
- COL4A3 Antibody (1042) is a mouse monoclonal IgG2b, cited in 9 publications, provided at 500 µl ascites
- raised against isolated placenta of human origin
- recommended for detection of Collagen α3 Type IV of human origin by WB, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COL4A3 Antibody (1042). This work is in progress.
COL4A3 Antibody (1042) is a mouse monoclonal IgG2b antibody that detects Collagen α3 Type IV (COL4A3) of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). COL4A3 (1042) antibody is available in a non-conjugated form, providing flexibility for various experimental needs. COL4A3 is a crucial component of the basement membrane, which serves as a supportive structure for tissues and organs. COL4A3′s proper function is vital for maintaining the integrity and stability of the extracellular matrix, influencing processes such as cell adhesion, migration, and differentiation. Abnormalities in COL4A3, including mutations in the COL4A3 gene, can lead to a range of diseases, including Alport syndrome, characterized by kidney dysfunction, hearing loss, and eye abnormalities. The unique triple helix structure of COL4A3 allows formation of networks that provide mechanical support and filtration properties in tissues, underscoring COL4A3′s importance in both health and disease. Anti-COL4A3 antibody (1042) enables researchers to gain valuable insights into COL4A3′s role in various biological processes and implications in pathological conditions.
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COL4A3 Antibody (1042) References:
- Retracted article | ..
- Collagen and bone strength. | Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
- Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways. | Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
- Type-IV collagen related diseases. | Pescucci, C., et al. 2003. J Nephrol. 16: 314-6. PMID: 12768082
- Discovery of type IV collagen non-collagenous domains as novel integrin ligands and endogenous inhibitors of angiogenesis. | Kalluri, R. 2002. Cold Spring Harb Symp Quant Biol. 67: 255-66. PMID: 12858548
- COL1A1, COL4A3, TIMP2 and TGFB1 polymorphisms in cervical insufficiency. | Alves, APVD., et al. 2021. J Perinat Med. 49: 553-558. PMID: 33550735
- Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in a Population Sequencing Database and Their Implications for Alport Syndrome. | Gibson, J., et al. 2021. J Am Soc Nephrol. 32: 2273-2290. PMID: 34400539
- Heterozygous COL4A3/COL4A4 mutations: the hidden part of the iceberg? | Mastrangelo, A., et al. 2022. Nephrol Dial Transplant. 37: 2398-2407. PMID: 35090027
- Abnormal mRNA Splicing Effect of COL4A3 to COL4A5 Unclassified Variants. | Zhang, Y., et al. 2023. Kidney Int Rep. 8: 1399-1406. PMID: 37441478
- Cell adhesion to collagenous matrices. | McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
- Versatile collagens in invertebrates. | Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
- The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. | Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COL4A3 Antibody (1042) | sc-52317 | 500 µl ascites | $322.00 |