COL4A Antibody (COL-94): sc-59814
- COL4A Antibody (COL-94) is a mouse monoclonal IgG1 COL4A antibody, cited in 22 publications, provided at 500 µl ascites
- raised against full length native Collagen Type IV of human origin
- recommended for detection of native, non-denatured, Collagen Type IV of human origin by WB, IF, IHC(P) and ELISA; non cross-reactive with Collagen Type I, II, III, V, VI or VII, human Vitronectin, Fibronectin or chondroitin sulfate A B and C, or denatured or denatured-reduced collagen in immunoblots
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COL4A Antibody (COL-94). This work is in progress.
COL4A Antibody (COL-94) is a mouse monoclonal IgG1 antibody that detects COL4A protein of human origin by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-COL4A antibody (COL-94) is available as a non-conjugated format. COL4A protein is a crucial component of type IV collagen, which forms the structural framework of basement membranes, providing support and anchorage for various tissues. COL4A′s unique structure, characterized by a triple helix domain, is essential for maintaining the integrity and stability of the extracellular matrix. This structural feature allows COL4A to interact with other proteins, such as laminins and nidogens, which are vital for the formation of functional basement membranes. The proper assembly and maintenance of these membranes are critical for tissue homeostasis, influencing processes such as filtration in the kidneys and providing a barrier in epithelial tissues. Disruptions in COL4A function can lead to various diseases, including Alport syndrome and other connective tissue disorders, highlighting the importance of this protein in both health and disease.
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COL4A Antibody (COL-94) References:
- Collagen and bone strength. | Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
- Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways. | Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
- Type-IV collagen related diseases. | Pescucci, C., et al. 2003. J Nephrol. 16: 314-6. PMID: 12768082
- Discovery of type IV collagen non-collagenous domains as novel integrin ligands and endogenous inhibitors of angiogenesis. | Kalluri, R. 2002. Cold Spring Harb Symp Quant Biol. 67: 255-66. PMID: 12858548
- Effects of type IV collagen and laminin on the cryopreservation of human embryonic stem cells. | Kim, SJ., et al. 2004. Stem Cells. 22: 950-61. PMID: 15536186
- Cell adhesion to collagenous matrices. | McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
- Versatile collagens in invertebrates. | Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
- The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. | Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COL4A Antibody (COL-94) | sc-59814 | 500 µl ascites | $316.00 |