COL1A1 Antibody (H-7): sc-518272

COL1A1 Antibody (H-7) is a monoclonal antibody that detects COL1A1 in human samples through western blotting (WB), immunofluorescence (IF), and immunoprecipitation (IP). Anti-COL1A1 antibody (H-7) enables detection of collagen type I alpha 1, a crucial component of the extracellular matrix that provides structural support to tissues and maintains the integrity of skin, bone, and connective tissues. COL1A1 forms fibrils in the extracellular space, contributing to tissue tensile strength and elasticity. COL1A1 (H-7) antibody supports research in wound healing, tissue repair, fibrosis, and osteogenesis imperfecta by enabling precise detection and analysis of collagen type I alpha 1 across different molecular biology assays.

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COL1A1 Antibody (H-7) References:

1. Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover.  |  Keen, RW., et al. 1999. Arthritis Rheum. 42: 285-90. PMID: 10025922
2. A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR.  |  Zhuang, JP., et al. 1991. Am J Hum Genet. 48: 1186-91. PMID: 2035536
3. NF-κB accumulation associated with COL1A1 transactivators defects during chronological aging represses type I collagen expression through a -112/-61-bp region of the COL1A1 promoter in human skin fibroblasts.  |  Bigot, N., et al. 2012. J Invest Dermatol. 132: 2360-2367. PMID: 22673730
4. Genetic polymorphisms of collagen type I α1 chain (COL1A1) gene increase the frequency of low bone mineral density in the subgroup of children with juvenile idiopathic arthritis.  |  Kostik, MM., et al. 2013. EPMA J. 4: 15. PMID: 23763832
5. Collagen type I alpha 1 gene polymorphism in premature ovarian failure.  |  Vujović, S., et al. 2013. Srp Arh Celok Lek. 141: 344-8. PMID: 23858805
6. Complete nucleotide sequence of the region encompassing the first twenty-five exons of the human pro alpha 1(I) collagen gene (COL1A1).  |  D'Alessio, M., et al. 1988. Gene. 67: 105-15. PMID: 2843432
7. Collagen 1A1 (COL1A1) promotes metastasis of breast cancer and is a potential therapeutic target.  |  Liu, J., et al. 2018. Discov Med. 25: 211-223. PMID: 29906404
8. Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p.  |  Yu, L., et al. 2021. J Extracell Vesicles. 10: e12056. PMID: 33489015
9. COL1A1 and COL1A2 variants in Ehlers-Danlos syndrome phenotypes and COL1-related overlap disorder.  |  Venable, E., et al. 2023. Am J Med Genet C Semin Med Genet. 193: 147-159. PMID: 36896471
10. Matrix metalloproteinase-2 inducing COL1A1 synthesis via integrin alpha Ⅴ promotes invasion and metastasis of cholangiocarcinoma cells.  |  Pan, S., et al. 2024. Ann Hepatol. 29: 101279. PMID: 38123132
11. The transcription of human alpha 1(I) procollagen gene (COL1A1) is suppressed by tumour necrosis factor-alpha through proximal short promoter elements: evidence for suppression mechanisms mediated by two nuclear-factorbinding sites.  |  Mori, K., et al. 1996. Biochem J. 319 (Pt 3): 811-6. PMID: 8920984

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL1A1 Antibody (H-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-COL1A1 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL1A1 Antibody (H-7) Specifications

Alternate Product Name: COL1A1

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1194-1219

Epitope Target: COL1A1

Epitope Species: human

Product Reactivity/Detection: COL1A1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for COL1A1 Antibody (H-7): N/A