COG7 Antibody (G-1): sc-271699

COG7 Antibody (G-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects COG7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). COG7 (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COG7, also known as CDG2E, is a crucial component of the conserved oligomeric Golgi (COG) complex, which plays a vital role in maintaining the structure and function of the Golgi apparatus. This complex is essential for proper glycosylation reactions and vesicular transport, consisting of three subcomplexes—LDLC, SEC34, and GTT—that work together to facilitate these processes. COG7, a 770 amino acid peripheral membrane protein, mediates vesicle docking and fusion, ensuring proteins are correctly modified and transported within cells. Defects in COG7 can lead to congenital disorder of glycosylation type 2E (CDG2E), a serious inherited condition characterized by under-glycosylated serum proteins, psychomotor retardation, hypotonia, coagulation disorders, and immunodeficiency, highlighting COG7′s critical role in cellular function and human health.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

COG7 Antibody (G-1) References:

1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.  |  Ungar, D., et al. 2002. J Cell Biol. 157: 405-15. PMID: 11980916
2. Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder.  |  Wu, X., et al. 2004. Nat Med. 10: 518-23. PMID: 15107842
3. Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.  |  Oka, T., et al. 2005. J Biol Chem. 280: 32736-45. PMID: 16051600
4. COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.  |  Shestakova, A., et al. 2006. Traffic. 7: 191-204. PMID: 16420527
5. COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins.  |  Steet, R. and Kornfeld, S. 2006. Mol Biol Cell. 17: 2312-21. PMID: 16510524
6. A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia.  |  Morava, E., et al. 2007. Eur J Hum Genet. 15: 638-45. PMID: 17356545
7. COG5-CDG: expanding the clinical spectrum.  |  Rymen, D., et al. 2012. Orphanet J Rare Dis. 7: 94. PMID: 23228021
8. Wrinkled skin and fat pads in patients with ALG8-CDG: revisiting skin manifestations in congenital disorders of glycosylation.  |  Kouwenberg, D., et al. 2014. Pediatr Dermatol. 31: e1-5. PMID: 24555185
9. Congenital disorders of glycosylation with emphasis on cerebellar involvement.  |  Barone, R., et al. 2014. Semin Neurol. 34: 357-66. PMID: 25192513
10. More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects.  |  Blackburn, JB., et al. 2018. Traffic. 19: 463-480. PMID: 29573151
11. Congenital myasthenic syndrome in China: genetic and myopathological characterization.  |  Zhao, Y., et al. 2021. Ann Clin Transl Neurol. 8: 898-907. PMID: 33756069
12. Characterization of a missense variant in COG5 in a Tunisian patient with COG5-CDG syndrome and insights into the effect of non-synonymous variants on COG5 protein.  |  Khabou, B., et al. 2024. J Hum Genet. 69: 591-597. PMID: 38987656

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COG7 Antibody (G-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-COG7 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COG7 Antibody (G-1) Specifications

Alternate Product Name: COG7

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-300

Epitope Target: COG7

Epitope Species: human

Product Reactivity/Detection: COG7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for COG7 Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin