CNPase Antibody (F-10): sc-166559

CNPase Antibody (F-10) is a mouse monoclonal IgG2b antibody that detects 2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CNPase plays a crucial role as a microtubule-associated protein, facilitating the assembly of microtubules, which are essential for maintaining cellular structure and function. The C-terminus of CNPase is particularly important for microtubule-promoting activity, highlighting CNPase significance in cytoskeletal dynamics. CNPase is predominantly located in the central nervous system, found in high concentrations within myelin and the outer segments of photoreceptors in the retina, underscoring CNPase vital role in neuronal health and visual function. Disruptions in CNPase activity, such as those caused by acute lead intoxication, can lead to detrimental effects on myelin morphology, further emphasizing CNPase importance in maintaining nervous system integrity. Anti-CNPase antibody (F-10) is an invaluable tool for researchers studying neurobiology and related fields, providing insights into mechanisms underlying microtubule dynamics and their implications in health and disease.

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CNPase Antibody (F-10) References:

1. Acute lead intoxication in vivo affects myelin membrane morphology and CNPase activity.  |  Dabrowska-Bouta, B., et al. 2000. Exp Toxicol Pathol. 52: 257-63. PMID: 10930127
2. CNPase activity in myelin from adult rat brains after prolonged lead exposure in vivo.  |  Dabrowska-Bouta, B., et al. 2004. Chem Biol Interact. 150: 171-8. PMID: 15535987
3. Differential RIP antigen (CNPase) expression in peripheral ensheathing glia.  |  Toma, JS., et al. 2007. Brain Res. 1137: 1-10. PMID: 17229407
4. Effect of lipid peroxidation on Na+,K(+)-ATPase, 5'-nucleotidase and CNPase in mouse brain myelin.  |  Domanska-Janik, K. and Bourre, JM. 1990. Biochim Biophys Acta. 1034: 200-6. PMID: 2162209
5. Downregulation of CNPase in a MeCP2 deficient mouse model of Rett syndrome.  |  Wu, W., et al. 2012. Neurol Res. 34: 107-13. PMID: 22334035
6. Identification of phosphorylated form of 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) as 46 kDa phosphoprotein in brain non-synaptic mitochondria overloaded by calcium.  |  Azarashvili, T., et al. 2014. J Bioenerg Biomembr. 46: 135-45. PMID: 24532135
7. Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase.  |  Muruganandam, G., et al. 2017. BMC Biochem. 18: 7. PMID: 28511668
8. Normal pressure hydrocephalus decreases the proliferation of oligodendrocyte progenitor cells and the expression of CNPase and MOG proteins in the corpus callosum before behavioral deficits occur.  |  Campos-Ordoñez, T., et al. 2023. Exp Neurol. 365: 114412. PMID: 37075967
9. Evaluation of CNPase and TGFβ1/Smad Signalling Pathway Molecule Expression in Sinus Epithelial Tissues of Patients with Chronic Rhinosinusitis with (CRSwNP) and without Nasal Polyps (CRSsNP).  |  Piszczatowska, K., et al. 2024. J Pers Med. 14: PMID: 39338148
10. CNPase expression in the developing opossum brain stem and cerebellum.  |  Barradas, PC., et al. 1995. Neuroreport. 6: 289-92. PMID: 7756612

The preferred CNPase antibody is CNPase Antibody (H-2): sc-166558.