CMV pp72/86 Antibody (CH160): sc-69748

CMV pp72/86 Antibody (CH160) is a mouse monoclonal IgG1 antibody that detects the CMV pp72/86 protein of CMV origin by western blotting (WB) and immunofluorescence (IF). Anti-CMV pp72/86 antibody (CH160) is available as the non-conjugated format. Cytomegalovirus (CMV), also known as human herpesvirus 5 (HHV-5), is a member of the herpes virus family, which includes other notable viruses such as herpes simplex virus types 1 and 2, Varicella Zoster Virus, and Epstein Barr virus. While CMV typically causes mild symptoms in healthy individuals, CMV can lead to severe complications in immunocompromised patients. CMV pp72 protein plays a crucial role during the viral lifecycle, particularly in the regulation of immune responses. CMV pp72 interacts with CMV pp86 protein to enhance the expression of HLA-G, a non-classical major histocompatibility complex (MHC) class I molecule that helps the virus evade the host′s immune system. This interaction is vital for the virus′s ability to persist in the host and can influence the outcome of CMV infection, making the study of these proteins essential for understanding CMV pathogenesis and developing potential therapeutic strategies.

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CMV pp72/86 Antibody (CH160) References:

1. Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection.  |  Onno, M., et al. 2000. J Immunol. 164: 6426-34. PMID: 10843698
2. Antisense oligonucleotide ISIS 2922 targets IE-expression and prevents HCMV-IE-induced suppression of TSP-1 and TSP-2 expression.  |  Margraf, S., et al. 2001. Nucleosides Nucleotides Nucleic Acids. 20: 1425-8. PMID: 11563036
3. Kinetics of HCMV immediate early mRNA expression in stably transfected fibroblasts.  |  Snaar, SP., et al. 2002. J Cell Sci. 115: 321-8. PMID: 11839784
4. Comparative analysis of CD8+ T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotype.  |  Khan, N., et al. 2002. J Infect Dis. 185: 1025-34. PMID: 11930311
5. Comparison of hCMV immediate early and CaMV 35S promoters in both plant and human cells.  |  Vlasák, J., et al. 2003. J Biotechnol. 103: 197-202. PMID: 12890606
6. Evaluation of a microtiter plate fluorescent-antibody assay for rapid detection of human cytomegalovirus infection.  |  Boppana, SB., et al. 1992. J Clin Microbiol. 30: 721-3. PMID: 1313050
7. CD8(+) T-cell immunity to cytomegalovirus.  |  Moss, P. and Khan, N. 2004. Hum Immunol. 65: 456-64. PMID: 15172445
8. Simultaneous generation of cytomegalovirus-specific CD8+ and CD4+ T lymphocytes by use of dendritic cells comodified with pp65 mRNA and pp65 protein.  |  Carlsson, B., et al. 2005. J Infect Dis. 192: 1912-20. PMID: 16267762
9. Comparison of HCMV IE and EF-1 promoters for the stable expression of beta-subunit of hexosaminidase in CHO cell lines.  |  Sinici, I., et al. 2006. Biochem Genet. 44: 173-80. PMID: 16645900

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CMV pp72/86 Antibody (CH160) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CMV pp72/86 Antibody (CH160) Specifications

Alternate Product Name: CMV pp72/86

Product Clone Name: CH160

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CMV pp72/86

Epitope Species: CMV

Product Reactivity/Detection: pp72 and pp86

Species Reactivity/Detection: CMV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CMV pp72/86 Antibody (CH160): N/A

The preferred CMV pp72 antibody is CMV pp72 Antibody (6E1): sc-69834.