CMPK Antibody (F-5): sc-376209

CMPK Antibody (F-5) is a mouse monoclonal IgG2b antibody that detects Cytidine monophosphate kinase (CMPK) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CMPK is a crucial enzyme composed of 196 amino acids that facilitates the phosphoryl transfer from adenosine triphosphate (ATP) to uridine monophosphate (UMP), cytidine monophosphate (CMP), and deoxycytidine monophosphate (dCMP), resulting in the production of adenosine diphosphate (ADP) and the corresponding nucleoside diphosphate. This enzymatic activity is vital for cellular nucleic acid synthesis, making CMPK essential for the pharmacological activation of therapeutic nucleosides and nucleotide analogs, particularly in the context of cancer and viral infections. Primarily localized in the cytoplasm, CMPK′s role extends to the activation of pyrimidine analogs, which are significant in the development of clinically relevant anti-cancer and anti-viral drugs. Notably, CMP is the preferred substrate for CMPK, followed by UMP and dCMP, underscoring the enzyme′s specificity and importance in nucleotide metabolism. Anti-CMPK antibody (F-5) is an invaluable tool for researchers investigating the mechanisms of nucleic acid synthesis and the therapeutic potential of nucleotide analogs.

The preferred CMPK antibody is CMPK Antibody (H-2): sc-376153.