CLASP2 Antibody (A-6): sc-514839
- CLASP2 Antibody (A-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 332-357 within an internal region of CLASP2 of human origin
- recommended for detection of CLASP2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CLASP2 Antibody (A-6) for WB applications. These reagents are now offered in bundles with CLASP2 Antibody (A-6) (see ordering information below).
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CLASP2 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects CLASP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLASP2, also known as KIAA0627 or hOrbit2, is a 1,294 amino acid protein characterized by five HEAT repeats, and is primarily localized in the cytoplasm, cytoskeleton, kinetochore, and Golgi apparatus. CLASP2 plays a critical role as a microtubule plus-end tracking protein, essential for regulating the stability of dynamic microtubules, which is vital for proper polarization of cytoplasmic microtubule arrays in migrating cells. CLASP2 interaction with proteins such as EB1, EB3, ELKS, and CLIP-115 not only stabilizes microtubules but also ensures kinetochore integrity, crucial for accurate chromosomal alignment during cell division. Additionally, CLASP2 undergoes phosphorylation by GSK-3β, a modification that negatively impacts microtubule binding ability, highlighting the importance of post-translational modifications in regulating function. Notably, two isoforms of CLASP2, designated beta and gamma, arise from alternative splicing, further diversifying functional roles in cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLASP2 Antibody (A-6) | sc-514839 | 200 µg/ml | $322.00 | |||
CLASP2 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-540998 | 200 µg Ab; 10 µg BP | $361.00 | |||
CLASP2 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-542520 | 200 µg Ab; 20 µg BP | $361.00 | |||
CLASP2 (A-6) Neutralizing Peptide | sc-514839 P | 100 µg/0.5 ml | $69.00 |