CLASP2 Activators
CLASP2 Activators encompass a range of chemical compounds that indirectly promote the functional activity of CLASP2 by influencing different cellular signaling pathways and microtubule dynamics. Forskolin, by raising intracellular cAMP levels, indirectly enhances CLASP2's role in stabilizing microtubule plus ends, as the elevated cAMP activates PKA, which can lead to phosphorylation of substrates including microtubule-associated proteins. PMA activates PKC, potentially affecting CLASP2's function in the cortical stabilization of microtubules. CLASP2 Activators consist of a diverse collection of chemical compounds that indirectly support the functional activity of CLASP2 by modulating various cellular signaling pathways and affecting microtubule dynamics. Forskolin indirectly amplifies CLASP2's role in microtubule stabilization by increasing cAMP within the cell, which subsequently activates PKA, potentially leading to the phosphorylation of proteins that interact with microtubules. Similarly, the activation of PKC by PMA may influence CLASP2's capacity to stabilize microtubules at their growing plus ends and within the cell cortex. Lithium Chloride, through its inhibition of GSK-3β, is posited to support the stabilization of microtubule-associated proteins, thereby potentially boosting the activity of CLASP2.
Advanced techniques, including structure-activity relationship studies and computational modeling, have been integral to refining the understanding of how CLASP2 activators interact with cellular components, influencing CLASP2 expression. The synthesis of these activators has been guided by meticulous design strategies to ensure the production of compounds with optimal pharmacokinetic and pharmacodynamic properties. Additionally, innovative approaches such as high-throughput screening and molecular dynamics simulations have facilitated the identification of specific binding sites and conformational changes associated with the activation of CLASP2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase leading to increased cAMP levels in the cell, which in turn activates PKA. PKA phosphorylates various proteins, potentially including CLASP2, thereby possibly enhancing its microtubule stabilization role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate proteins involved in microtubule dynamics, possibly influencing CLASP2's function in microtubule stabilization at the plus ends and at the cell cortex. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, which can lead to stabilization of microtubule-associated proteins. Since CLASP2 is involved in microtubule stabilization, inhibition of GSK-3β could enhance the functional activity of CLASP2. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which includes downstream effects on microtubule dynamics. PI3K/Akt pathway activation could, therefore, enhance the microtubule stabilization role of CLASP2. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, potentially increasing the demand for CLASP2's microtubule plus-end stabilization activity. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is an inhibitor of the mitotic kinesin Eg5, which may affect microtubule dynamics during mitosis. This could lead to increased reliance on microtubule stabilization by CLASP2. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $147.00 $1029.00 $1632.00 $3264.00 $4296.00 | 1 | |
BI 2536 is a polo-like kinase 1 (Plk1) inhibitor, which can disrupt spindle dynamics during cell division, potentially enhancing the functional activity of CLASP2 in stabilizing microtubules. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor, which affects spindle assembly and microtubule dynamics. By inhibiting Aurora kinase, it could indirectly enhance the microtubule stabilization function of CLASP2. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a CDK inhibitor that may affect cell cycle progression and microtubule assembly, potentially leading to enhanced activity of CLASP2 in its role of microtubule stabilization. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA, leading to phosphorylation of various targets involved in the regulation of microtubule dynamics, potentially enhancing the activity of CLASP2 in microtubule stabilization. | ||||||