CIN85 Antibody (G-12): sc-271310
- CIN85 Antibody (G-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 366-665 mapping at the C-terminus of CIN85 of human origin
- recommended for detection of CIN85 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CIN85 Antibody (G-12) for WB applications. These reagents are now offered in bundles with CIN85 Antibody (G-12) (see ordering information below).
QUICK LINKS
SEE ALSO...
CIN85 Antibody (G-12) is a mouse monoclonal IgG2a antibody that detects CIN85 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CIN85 is a crucial adaptor protein that plays a significant role in cellular signaling by interacting with various proteins, including receptor tyrosine kinases and components of the endocytic machinery. CIN85′s ability to form multimeric complexes is essential for regulating processes such as T-cell activation and apoptosis in neuronal cells. CIN85′s structure, characterized by three SH3 domains, a proline-rich region, and a coiled-coil domain, is vital for function, as these domains facilitate specific protein-protein interactions necessary for signaling complex assembly. Through coordinated interactions, CIN85 contributes to downregulation and degradation of receptor tyrosine kinases, thereby influencing cellular responses to external signals. Anti-CIN85 antibody (G-12) serves as an invaluable tool for researchers studying these complex signaling pathways and their implications in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CIN85 Antibody (G-12) References:
- CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. | Shimokawa, N., et al. 2010. EMBO J. 29: 2421-32. PMID: 20551902
- CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor. | Rønning, SB., et al. 2011. Exp Cell Res. 317: 1804-16. PMID: 21635887
- CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells. | Niiro, H., et al. 2012. Blood. 119: 2263-73. PMID: 22262777
- Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587. | Bior, BK. and Ballif, BA. 2013. FEBS Lett. 587: 60-6. PMID: 23178720
- CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface. | Yakymovych, I., et al. 2015. J Cell Biol. 210: 319-32. PMID: 26169354
- CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. | Teng, B., et al. 2016. Diabetes. 65: 3667-3679. PMID: 27531950
- High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma. | Hua, XY., et al. 2021. Mol Med Rep. 23: PMID: 33179079
- E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis. | Ahmed, SF., et al. 2021. Oncogene. 40: 2149-2164. PMID: 33627783
- The Rab GTPase-binding protein EHBP1L1 and its interactors CD2AP/CIN85 negatively regulate the length of primary cilia via actin remodeling. | Iwano, T., et al. 2023. J Biol Chem. 299: 102985. PMID: 36754282
- Quantitative description of the phase-separation behavior of the multivalent SLP65-CIN85 complex. | Maier, J., et al. 2024. PNAS Nexus. 3: pgae079. PMID: 38463037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CIN85 Antibody (G-12) | sc-271310 | 200 µg/ml | $322.00 | |||
CIN85 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-537608 | 200 µg Ab; 10 µg BP | $361.00 | |||
CIN85 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-534924 | 200 µg Ab; 40 µg BP | $361.00 | |||
CIN85 Antibody (G-12): m-IgG2a BP-HRP Bundle | sc-548065 | 200 µg Ab; 10 µg BP | $361.00 |