CIN85 Antibody (E-1): sc-377342
- CIN85 Antibody (E-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 495-531 within an internal region of CIN85 of mouse origin
- recommended for detection of CIN85 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CIN85 Antibody (E-1) for WB applications. These reagents are now offered in bundles with CIN85 Antibody (E-1) (see ordering information below).
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CIN85 Antibody (E-1) is a mouse monoclonal IgG2b antibody that detects CIN85 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CIN85 is a crucial adaptor protein that plays a significant role in cellular signaling by interacting with various proteins to form multimeric complexes. CIN85 is primarily located in the cytoplasm and is essential for the regulation of receptor tyrosine kinase signaling pathways, which are vital for processes such as cell growth, differentiation, and survival. The ability of CIN85 to associate with other endocytic proteins and components of the actin cytoskeleton highlights its importance in modulating endocytosis and receptor downregulation. By facilitating these interactions, CIN85 contributes to the fine-tuning of cellular responses to external signals, making CIN85 a key player in maintaining cellular homeostasis and function. Anti-CIN85 antibody (E-1) is an invaluable tool for researchers studying these complex signaling networks and their implications in various physiological and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CIN85 Antibody (E-1) References:
- Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. | Schmidt, MHH., et al. 2004. Mol Cell Biol. 24: 8981-93. PMID: 15456872
- CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis. | Narita, T., et al. 2005. Exp Cell Res. 304: 256-64. PMID: 15707590
- Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. | Haglund, K., et al. 2005. EMBO Rep. 6: 635-41. PMID: 15962011
- Overexpression of CIN85 suppresses the growth of herpes simplex virus in HeLa cells. | Narita, T., et al. 2005. Exp Cell Res. 311: 265-71. PMID: 16223483
- Expression of adaptor protein Ruk/CIN85 isoforms in cell lines of various tissue origins and human melanoma. | Mayevska, O., et al. 2006. Exp Oncol. 28: 275-81. PMID: 17285110
- The adaptor protein Ruk/CIN85 activates plasminogen activator inhibitor-1 (PAI-1) expression via hypoxia-inducible factor-1alpha. | Samoylenko, A., et al. 2010. Thromb Haemost. 103: 901-9. PMID: 20216986
- Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. | Kedar, VP., et al. 2010. PLoS One. 5: e9588. PMID: 20221403
- CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes. | Tossidou, I., et al. 2010. J Biol Chem. 285: 25285-95. PMID: 20457601
- ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking. | Yoon, HY., et al. 2011. Biol Cell. 103: 171-84. PMID: 21275903
- Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587. | Bior, BK. and Ballif, BA. 2013. FEBS Lett. 587: 60-6. PMID: 23178720
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CIN85 Antibody (E-1) | sc-377342 | 200 µg/ml | $316.00 | |||
CIN85 Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-538039 | 200 µg Ab; 10 µg BP | $354.00 | |||
CIN85 Antibody (E-1): m-IgGκ BP-HRP Bundle | sc-535563 | 200 µg Ab; 40 µg BP | $354.00 | |||
CIN85 (E-1) Neutralizing Peptide | sc-377342 P | 100 µg/0.5 ml | $68.00 |