CIB Antibody (E-9): sc-271041

CIB Antibody (E-9) is a mouse monoclonal IgG2b antibody that detects calcium- and integrin-binding protein (CIB) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CIB plays a crucial role in cellular signaling and regulation, particularly in platelets where CIB interacts with integrin α2b/β3, the fibrinogen receptor essential for platelet aggregation and clot formation. The binding of CIB to the cytoplasmic domain of α2b is influenced by intracellular calcium levels, highlighting the importance of calcium signaling in platelet function. CIB′s ability to translocate to the Triton X-100-insoluble cytoskeleton in aggregated platelets indicates dynamic cellular localization, which is vital for regulatory functions. Beyond platelets, CIB also interacts with DNA-PKcs, a key protein involved in DNA repair and lymphoid development, suggesting broader implications in cellular processes. With significant homology to calcineurin B and calmodulin, CIB′s expression across various human tissues underscores potential importance in diverse biological contexts. Anti-CIB antibody (E-9) is an essential tool for researchers studying the intricate roles of CIB in cellular signaling and implications in health and disease.

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CIB Antibody (E-9) References:

1. Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).  |  Ritzel, MW., et al. 2001. Mol Membr Biol. 18: 65-72. PMID: 11396613
2. The human complement factor H: functional roles, genetic variations and disease associations.  |  Rodríguez de Córdoba, S., et al. 2004. Mol Immunol. 41: 355-67. PMID: 15163532
3. CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein.  |  Terui, H., et al. 2013. J Biomed Sci. 20: 25. PMID: 23621914
4. Clinical applicability of optogenetic gene regulation.  |  Wichert, N., et al. 2021. Biotechnol Bioeng. 118: 4168-4185. PMID: 34287844
5. Generation of a human iPSC line CIBi010-A with a reporter for ASGR1 using CRISPR/Cas9.  |  Fu, J., et al. 2022. Stem Cell Res. 62: 102800. PMID: 35561459
6. Functional Analysis of Lactic Acid Bacteria and Bifidobacteria and Their Effects on Human Health.  |  Dueñas, MT. and López, P. 2022. Foods. 11: PMID: 35954061
7. Feto-placental Unit: From Development to Function.  |  Covarrubias, A., et al. 2023. Adv Exp Med Biol. 1428: 1-29. PMID: 37466767
8. Comparing human and animal antimicrobial usage: a critical appraisal of the indicators used is needed.  |  Sanders, P., et al. 2024. JAC Antimicrob Resist. 6: dlae005. PMID: 38268966
9. A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis.  |  Zelante, T., et al. 2024. Sci Rep. 14: 6651. PMID: 38509264
10. Blue Light-Induced, Dosed Protein Expression of Active BDNF in Human Cells Using the Optogenetic CRY2/CIB System.  |  Christoffers, S., et al. 2024. Biotechnol J. 19: e202400384. PMID: 39726067

The preferred CIB antibody is CIB Antibody (G-5): sc-271490.