CHMP5 Antibody (D-11): sc-374337

CHMP5 Antibody (D-11) is a mouse monoclonal IgG1 antibody that detects CHMP5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CHMP5, a member of the charged multivesicular body proteins (CHMPs), plays a pivotal role in the endosomal sorting complex required for transport (ESCRT) machinery, which is essential for the formation of multivesicular bodies (MVBs). These MVBs are critical for the degradation of cellular components and the regulation of signaling pathways, as MVBs facilitate the sorting of endosomal cargo. CHMP5 interacts with LIP5, a protein necessary for the release of HIV-1, highlighting CHMP5′s importance in viral budding processes. CHMP5 levels maintain a crucial balance; depletion of CHMP5 can lead to increased HIV-1 release, while CHMP5 overexpression can inhibit viral budding. Additionally, CHMP5 is involved in late endosomal development, and CHMP5 loss can disrupt lysosomal degradation, resulting in enhanced signal transduction. anti-CHMP5 antibody (D-11) is an invaluable tool for researchers studying the dynamics of endosomal trafficking and implications in viral infections and cellular signaling.

The preferred CHMP5 antibody is CHMP5 Antibody (F-7): sc-374338.