CHMP1A Antibody (B-5): sc-271617

CHMP1A Antibody (B-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CHMP1A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CHMP1A (B-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CHMP1A protein plays a vital role in the endosomal sorting process, as CHMP1A serves as a key component of the endosomal sorting complex required for transport (ESCRT) machinery, which is essential for the formation of multivesicular bodies (MVBs). These structures are crucial for the degradation of membrane proteins and the regulation of various cellular processes, including receptor downregulation and the release of exosomes. CHMP1A interacts with VPS4B, a protein involved in the disassembly of ESCRT complexes, and primarily localizes to early endosomes, where CHMP1A facilitates the sorting of endosomal cargo. Notably, there are two isoforms of CHMP1, CHMP1A and CHMP1B, which are encoded by distinct genes and may have different regulatory roles in cellular processes. Overexpression of CHMP1A can lead to the dilation of endosomal compartments, disrupting the normal distribution of endosomal markers and potentially contributing to various pathophysiological conditions.

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CHMP1A Antibody (B-5) References:

1. CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression.  |  Stauffer, DR., et al. 2001. J Cell Sci. 114: 2383-93. PMID: 11559747
2. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.  |  Howard, TL., et al. 2001. J Cell Sci. 114: 2395-404. PMID: 11559748
3. Molecular characterization of NbCHMP1 encoding a homolog of human CHMP1 in Nicotiana benthamiana.  |  Yang, KS., et al. 2004. Mol Cells. 17: 255-61. PMID: 15179039
4. The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B.  |  Reid, E., et al. 2005. Hum Mol Genet. 14: 19-38. PMID: 15537668
5. CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway.  |  Horii, M., et al. 2006. Biochem J. 400: 23-32. PMID: 16856878

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CHMP1A Antibody (B-5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CHMP1A Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CHMP1A Antibody (B-5) Specifications

Alternate Product Name: CHMP1A

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-196

Epitope Target: CHMP1A

Epitope Species: human

Product Reactivity/Detection: CHMP1A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CHMP1A Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CHMP1B antibody is CHMP1B Antibody (D-10): sc-514013.