cHMGCS Antibody (C-8): sc-271543

cHMGCS Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects cHMGCS in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). cHMGCS, or cytoplasmic HMG-CoA synthase, plays a crucial role in the mevalonate pathway, which is essential for the biosynthesis of isoprenoids, including cholesterol and other vital biomolecules. This enzyme catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is subsequently converted into mevalonate by HMG-CoA reductase, marking the beginning of isoprenoid biosynthesis. cHMGCS functions extend beyond cholesterol production, contributing to the synthesis of ubiquinone, dolichol, and farnesyl groups, all critical for cellular function and membrane integrity. cHMGCS is predominantly expressed in the liver and kidney, and expression is tightly regulated by nutritional states, with fasting and elevated levels of cAMP and fatty acids enhancing transcription, while feeding and insulin exert a repressive effect. Understanding the regulation and function of cHMGCS is vital, as dysregulation of this pathway can lead to metabolic disorders and cardiovascular diseases. Anti-cHMGCS antibody (C-8) serves as an invaluable tool for researchers investigating the role of this enzyme in health and disease.

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cHMGCS Antibody (C-8) References:

1. Exercise Training Reverses Lipotoxicity-induced Cardiomyopathy by Inhibiting HMGCS2.  |  Li, S., et al. 2021. Med Sci Sports Exerc. 53: 47-57. PMID: 32826638
2. Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries.  |  Tan, W., et al. 2023. Curr Mol Med. 23: 1104-1115. PMID: 36281857
3. HMGCS2-Induced Autophagic Degradation of Tau Involves Ketone Body and ANKRD24.  |  Hu, LT., et al. 2023. J Alzheimers Dis. 91: 407-426. PMID: 36442191
4. Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress.  |  Martín-Adrados, B., et al. 2023. Front Immunol. 14: 1185517. PMID: 37457727
5. Hmgcs2 regulates M2 polarization of macrophages to repair myocardial injury induced by sepsis.  |  Zou, XZ., et al. 2023. Aging (Albany NY). 15: 7794-7810. PMID: 37561521
6. HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth.  |  Mao, H., et al. 2023. Sci Rep. 13: 14629. PMID: 37670031
7. Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway.  |  Shen, Y., et al. 2024. Phytomedicine. 126: 155445. PMID: 38412666
8. Hmgcs2 is the hub gene in diabetic cardiomyopathy and is negatively regulated by Hmgcs2, promoting high glucose-induced cardiomyocyte injury.  |  Wang, Y., et al. 2024. Immun Inflamm Dis. 12: e1191. PMID: 38477658
9. Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts.  |  Yang, J., et al. 2024. Respir Res. 25: 176. PMID: 38658970
10. Restoration of HMGCS2-mediated ketogenesis alleviates tacrolimus-induced hepatic lipid metabolism disorder.  |  Li, SL., et al. 2024. Acta Pharmacol Sin. 45: 1898-1911. PMID: 38760545

The preferred cHMGCS antibody is cHMGCS Antibody (A-6): sc-166763.