Date published: 2026-5-7

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cHMGCS Substrates

Santa Cruz Biotechnology now offers a broad range of cHMGCS Substrates for use in various applications. cHMGCS, or cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase, is a key enzyme involved in the biosynthesis of ketone bodies, playing a crucial role in energy metabolism, particularly during periods of fasting or low carbohydrate intake. cHMGCS Substrates are essential tools in scientific research for studying the enzymatic mechanisms that govern ketogenesis and the broader metabolic pathways associated with lipid metabolism. Researchers utilize these substrates to investigate the catalytic activity of cHMGCS, allowing for a detailed understanding of how this enzyme contributes to the synthesis of ketone bodies, which are vital energy sources for tissues such as the brain and muscles during prolonged fasting. These substrates are frequently employed in biochemical assays to explore the enzyme's kinetics, substrate specificity, and its regulation under various physiological conditions. In addition to their role in metabolism research, cHMGCS Substrates are used to study the impact of enzyme activity on metabolic disorders and how alterations in ketogenesis can affect overall energy balance in the body. The availability of these substrates has significantly advanced research in fields such as biochemistry, molecular biology, and metabolic studies, providing researchers with the necessary tools to dissect the complex processes involved in energy homeostasis. View detailed information on our available cHMGCS Substrates by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Acetoacetyl coenzyme A sodium salt

102029-52-7sc-252348
sc-252348B
5 mg
10 mg
$478.00
$843.00
(2)

Acetoacetyl coenzyme A sodium salt functions as a crucial substrate in the cHMGCS pathway, facilitating the condensation of acetyl-CoA and acetoacetyl-CoA. Its unique structure allows for efficient binding to active sites, promoting rapid reaction kinetics. The compound exhibits distinct hydrophilic and hydrophobic characteristics, influencing solubility and interaction with enzyme active sites. This dual nature enhances its role in metabolic flux, driving the synthesis of key intermediates in lipid biosynthesis.