Chk2 Antibody (A-11): sc-17747
- Chk2 Antibody (A-11) is a mouse monoclonal IgG1 κ Chk2 antibody, cited in 49 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of Chk2 of human origin
- Chk2 Antibody (A-11) is recommended for detection of Chk2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Chk2 Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to TRITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Chk2 Antibody (A-11) for WB applications. These reagents are now offered in bundles with Chk2 Antibody (A-11) (see ordering information below).
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Chk2 Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Chk2 of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Chk2 monoclonal antibody (A-11) is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Chk2 plays a critical role in the cellular response to DNA damage, functioning as a key regulator in the G2 DNA damage checkpoint. By phosphorylating Cdc25C in response to DNA damage, Chk2 inhibits the activity of this phosphatase, effectively blocking the progression of mitosis until the damage is repaired. This regulatory mechanism is vital for maintaining genomic stability, as preventing cells with damaged DNA from entering mitosis reduces the risk of propagating mutations. The interaction of Chk2 with other proteins, such as Cdc25C, highlights the importance in the intricate network of cell cycle regulation and DNA damage response, making Chk2 (A-11) antibody an essential tool for researchers studying these critical cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chk2 Antibody (A-11) | sc-17747 | 200 µg/ml | $322.00 | |||
Chk2 Antibody (A-11): m-IgG Fc BP-HRP Bundle | sc-526568 | 200 µg Ab; 10 µg BP | $361.00 | |||
Chk2 Antibody (A-11): m-IgG1 BP-HRP Bundle | sc-531941 | 200 µg Ab; 20 µg BP | $361.00 | |||
Chk2 Antibody (A-11) AC | sc-17747 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Chk2 Antibody (A-11) HRP | sc-17747 HRP | 200 µg/ml | $322.00 | |||
Chk2 Antibody (A-11) FITC | sc-17747 FITC | 200 µg/ml | $336.00 | |||
Chk2 Antibody (A-11) PE | sc-17747 PE | 200 µg/ml | $349.00 | |||
Chk2 Antibody (A-11) Alexa Fluor® 488 | sc-17747 AF488 | 200 µg/ml | $364.00 | |||
Chk2 Antibody (A-11) Alexa Fluor® 546 | sc-17747 AF546 | 200 µg/ml | $364.00 | |||
Chk2 Antibody (A-11) Alexa Fluor® 594 | sc-17747 AF594 | 200 µg/ml | $364.00 | |||
Chk2 Antibody (A-11) Alexa Fluor® 647 | sc-17747 AF647 | 200 µg/ml | $364.00 | |||
Chk2 Antibody (A-11) Alexa Fluor® 680 | sc-17747 AF680 | 200 µg/ml | $364.00 | |||
Chk2 Antibody (A-11) Alexa Fluor® 790 | sc-17747 AF790 | 200 µg/ml | $364.00 | |||
Chk2 Antibody (A-11) TRITC | sc-17747 TRITC | 200 µg/ml | $326.00 |