CHD9 Antibody (E-4): sc-390291

CHD9 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects CHD9 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CHD9 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CHD9, also known as chromodomain-helicase-DNA-binding protein 9, chromatin-related mesenchymal modulator (CReMM), or PPAR-alpha-interacting complex protein 320 kDa, is a 2,897 amino acid member of the Snf2/Rad54 helicase family. CHD9 plays a crucial role in chromatin remodeling, which is essential for regulating gene expression and maintaining genomic stability. CHD9 is localized in both the cytoplasm and nucleus, where CHD9 contains two chromodomains, an ATP-binding helicase domain, and a C-terminal helicase domain. The presence of chromodomains, which are highly conserved protein regions associated with chromatin manipulation, underscores CHD9′s importance in cellular processes. Additionally, CHD9 acts as a transcriptional coactivator for PPARα, highlighting CHD9′s role in lipid metabolism and energy homeostasis. CHD9 is expressed at low levels across various tissues and exists in three isoforms due to alternative splicing, further emphasizing CHD9′s functional diversity in cellular contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CHD9 Antibody (E-4) References:

1. Mammalian chromodomain proteins: their role in genome organisation and expression.  |  Jones, DO., et al. 2000. Bioessays. 22: 124-37. PMID: 10655032
2. Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein.  |  Shur, I. and Benayahu, D. 2005. J Mol Biol. 352: 646-55. PMID: 16095617
3. In vivo association of CReMM/CHD9 with promoters in osteogenic cells.  |  Shur, I., et al. 2006. J Cell Physiol. 207: 374-8. PMID: 16419031
4. Expression and regulation of CReMM, a chromodomain helicase-DNA-binding (CHD), in marrow stroma derived osteoprogenitors.  |  Marom, R., et al. 2006. J Cell Physiol. 207: 628-35. PMID: 16523501
5. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.  |  Surapureddi, S., et al. 2006. Biochem Biophys Res Commun. 343: 535-43. PMID: 16554032
6. Dynamic interactions of chromatin-related mesenchymal modulator, a chromodomain helicase-DNA-binding protein, with promoters in osteoprogenitors.  |  Shur, I., et al. 2006. Stem Cells. 24: 1288-93. PMID: 16705189
7. Insights on the functional role of chromatin remodelers in osteogenic cells.  |  Benayahu, D., et al. 2007. Crit Rev Eukaryot Gene Expr. 17: 103-13. PMID: 17725483

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CHD9 Antibody (E-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CHD9 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CHD9 Antibody (E-4) Specifications

Alternate Product Name: CHD9

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 225-514

Epitope Target: CHD9

Epitope Species: human

Product Reactivity/Detection: CHD9

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CHD9 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent