CHCHD5 Antibody (G-9): sc-514187
- CHCHD5 Antibody (G-9) is a mouse monoclonal IgG1 κ CHCHD5 antibody provided at 200 µg/ml
- raised against amino acids 44-96 mapping within an internal region of CHCHD5 of human origin
- CHCHD5 Antibody (G-9) is recommended for detection of CHCHD5 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-CHCHD5 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CHCHD5 Antibody (G-9) for WB applications. These reagents are now offered in bundles with CHCHD5 Antibody (G-9) (see ordering information below).
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CHCHD5 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects CHCHD5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CHCHD5 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CHCHD5, or coiled-coil-helix-coiled-coil-helix domain-containing protein 5, is a 110 amino acid protein characterized by the presence of one CHCH domain, which plays a crucial role in mitochondrial function and cellular respiration. CHCHD5 is primarily located in the mitochondria, where CHCHD5 is involved in the regulation of oxidative phosphorylation and the maintenance of mitochondrial integrity. Proper functioning of CHCHD5 is vital for energy production in cells, and disruptions in CHCHD5 activity can lead to mitochondrial dysfunction, which is implicated in various diseases, including neurodegenerative disorders and metabolic syndromes. The gene encoding CHCHD5 is situated on human chromosome 2, a region associated with several genetic diseases, highlighting the importance of CHCHD5 in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CHCHD5 Antibody (G-9) References:
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- Evidence for an ancestral alphoid domain on the long arm of human chromosome 2. | Avarello, R., et al. 1992. Hum Genet. 89: 247-9. PMID: 1587535
- ABCA12 is the major harlequin ichthyosis gene. | Thomas, AC., et al. 2006. J Invest Dermatol. 126: 2408-13. PMID: 16902423
- Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome. | Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
- Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis. | Akiyama, M., et al. 2007. Dermatology. 215: 155-9. PMID: 17684380
- Alström syndrome. | Marshall, JD., et al. 2007. Eur J Hum Genet. 15: 1193-202. PMID: 17940554
- Origin of human chromosome 2: an ancestral telomere-telomere fusion. | IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367
- Structural characterization of CHCHD5 and CHCHD7: two atypical human twin CX9C proteins. | Banci, L., et al. 2012. J Struct Biol. 180: 190-200. PMID: 22842048
- PTRHD1 (C2orf79) mutations lead to autosomal-recessive intellectual disability and parkinsonism. | Khodadadi, H., et al. 2017. Mov Disord. 32: 287-291. PMID: 27753167
- Identification of potential genetic causal variants for rheumatoid arthritis by whole-exome sequencing. | Li, Y., et al. 2017. Oncotarget. 8: 111119-111129. PMID: 29340042
- CHTM1, a novel metabolic marker deregulated in human malignancies. | Babbar, M., et al. 2018. Oncogene. 37: 2052-2066. PMID: 29371680
- PTRHD1 Loss-of-function mutation in an african family with juvenile-onset Parkinsonism and intellectual disability. | Kuipers, DJS., et al. 2018. Mov Disord. 33: 1814-1819. PMID: 30398675
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CHCHD5 Antibody (G-9) | sc-514187 | 200 µg/ml | $322.00 | |||
CHCHD5 Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-531058 | 200 µg Ab; 10 µg BP | $361.00 | |||
CHCHD5 Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-524641 | 200 µg Ab, 40 µg BP | $361.00 | |||
CHCHD5 Antibody (G-9) AC | sc-514187 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CHCHD5 Antibody (G-9) HRP | sc-514187 HRP | 200 µg/ml | $322.00 | |||
CHCHD5 Antibody (G-9) FITC | sc-514187 FITC | 200 µg/ml | $336.00 | |||
CHCHD5 Antibody (G-9) PE | sc-514187 PE | 200 µg/ml | $349.00 | |||
CHCHD5 Antibody (G-9) Alexa Fluor® 488 | sc-514187 AF488 | 200 µg/ml | $364.00 | |||
CHCHD5 Antibody (G-9) Alexa Fluor® 546 | sc-514187 AF546 | 200 µg/ml | $364.00 | |||
CHCHD5 Antibody (G-9) Alexa Fluor® 594 | sc-514187 AF594 | 200 µg/ml | $364.00 | |||
CHCHD5 Antibody (G-9) Alexa Fluor® 647 | sc-514187 AF647 | 200 µg/ml | $364.00 | |||
CHCHD5 Antibody (G-9) Alexa Fluor® 680 | sc-514187 AF680 | 200 µg/ml | $364.00 | |||
CHCHD5 Antibody (G-9) Alexa Fluor® 790 | sc-514187 AF790 | 200 µg/ml | $364.00 |