CES1 Antibody (E-1): sc-365248

CES1 Antibody (E-1) is a mouse monoclonal IgG1 antibody that detects CES1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CES1, a member of the type-B carboxylesterase/lipase family, plays a vital role in the detoxification processes within the liver, hydrolyzing a variety of xenobiotics and therapeutic pro-drugs, which is essential for drug metabolism and clearance. Anti-CES1 antibody (E-1) targets proteins primarily located in the cytosol of liver cells, where CES1 facilitates the breakdown of ester and amide compounds, including narcotics and anti-tumor agents. CES1′s localization in the liver is particularly important as this placement allows for efficient detoxification and metabolism of drugs before entering systemic circulation, thereby influencing therapeutic efficacy and safety. CES1 exhibits a high affinity for aromatic and aliphatic esters, making CES1 a key player in the metabolism of various therapeutic agents. CES1 (E-1) antibody serves as an invaluable tool for researchers studying drug metabolism, liver function, and pharmacokinetics of therapeutic compounds, providing insights into mechanisms of action and potential interactions of drugs within the body.

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CES1 Antibody (E-1) References:

1. Human carboxylesterases: an update on CES1, CES2 and CES3.  |  Sanghani, SP., et al. 2009. Protein Pept Lett. 16: 1207-14. PMID: 19508181
2. Carboxylesterase 1 (Ces1): from monocyte marker to major player.  |  Markey, GM. 2011. J Clin Pathol. 64: 107-9. PMID: 21177752
3. The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.  |  Merali, Z., et al. 2014. Drug Metabol Drug Interact. 29: 143-51. PMID: 24988246
4. Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.  |  Her, LH., et al. 2021. Br J Clin Pharmacol. 87: 4691-4700. PMID: 33963573
5. Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.  |  Zhou, L., et al. 2021. Clin Transl Med. 11: e449. PMID: 34185414
6. Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis.  |  Li, H., et al. 2022. Front Cardiovasc Med. 9: 959916. PMID: 35990949
7. Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy.  |  Li, G., et al. 2023. JCI Insight. 8: PMID: 36472914
8. A near-infrared fluorescent probe based on a hemi-cyanine skeleton for detecting CES1 activity and evaluating pesticide toxicity.  |  Zhao, X., et al. 2023. J Mater Chem B. 11: 3587-3591. PMID: 37071077
9. CES1 Releases Oxylipins from Oxidized Triacylglycerol (oxTAG) and Regulates Macrophage oxTAG/TAG Accumulation and PGE2/IL-1β Production.  |  Phillips, ME., et al. 2023. ACS Chem Biol. 18: 1564-1581. PMID: 37348046
10. Pharmacogenetic study of CES1 gene and enalapril efficacy.  |  Hussain, M., et al. 2024. J Appl Genet. 65: 463-471. PMID: 38261266

The preferred CES1 antibody is CES1 Antibody (A-11): sc-365249.