Cdx4 Antibody (H-4): sc-374471
- Cdx4 Antibody (H-4) is a mouse monoclonal IgG1 κ Cdx4 antibody provided at 200 µg/ml
- raised against amino acids 1-168 mapping at the N-terminus of Cdx4 of mouse origin
- Cdx4 Antibody (H-4) is recommended for detection of Cdx4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Cdx4 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-374471 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cdx4 Antibody (H-4) for WB applications. These reagents are now offered in bundles with Cdx4 Antibody (H-4) (see ordering information below).
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Cdx4 Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cdx4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Cdx4 antibody (H-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cdx4 protein is a crucial transcription factor that plays a significant role in embryonic development by regulating the expression of Hox genes, which are essential for the proper formation of the vertebrate body plan. Specifically, Cdx4 is a major positive regulator of Hox gene expression, influencing the development of structures such as the central nervous system, heart, axial skeleton, limbs, and urogenital tract. Precise regulation of Cdx4 is vital, as Cdx4 is a direct target of the canonical Wnt signaling pathway; disruptions in Cdx4 levels can lead to developmental anomalies, such as an expanded hindbrain or a loss of segmental features in the hindbrain, which can result in conditions resembling spinal cord morphology. Cdx4 (H-4) monoclonal antibody effectively detects this important protein, making Cdx4 (H-4) antibody an invaluable tool for researchers studying developmental biology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdx4 Antibody (H-4) References:
- Cdx protein interaction with Hoxa5 regulatory sequences contributes to Hoxa5 regional expression along the axial skeleton. | Tabariès, S., et al. 2005. Mol Cell Biol. 25: 1389-401. PMID: 15684390
- cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse. | Gaunt, SJ., et al. 2005. Int J Dev Biol. 49: 901-8. PMID: 16281167
- Cdx4 is a direct target of the canonical Wnt pathway. | Pilon, N., et al. 2006. Dev Biol. 289: 55-63. PMID: 16309666
- Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. | Bansal, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 16924-9. PMID: 17068127
- Ex vivo expanding hematopoietic stem cells by intracellular delivery of Cdx4 fusion proteins. | Guo, XT., et al. 2007. Med Hypotheses. 68: 1389-91. PMID: 17196761
- Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. | Skromne, I., et al. 2007. Development. 134: 2147-58. PMID: 17507415
- A member of the caudal family of homeobox genes maps to the X-inactivation centre region of the mouse and human X chromosomes. | Horn, JM. and Ashworth, A. 1995. Hum Mol Genet. 4: 1041-7. PMID: 7655457
- Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. | Gamer, LW. and Wright, CV. 1993. Mech Dev. 43: 71-81. PMID: 7902125
- Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. | Bonner, CA., et al. 1995. Genomics. 28: 206-11. PMID: 8530027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdx4 Antibody (H-4) | sc-374471 | 200 µg/ml | $316.00 | |||
Cdx4 Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-529753 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cdx4 Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-522750 | 200 µg Ab, 40 µg BP | $354.00 | |||
Cdx4 Antibody (H-4): m-IgG1 BP-HRP Bundle | sc-543671 | 200 µg Ab; 20 µg BP | $354.00 | |||
Cdx4 Antibody (H-4) X | sc-374471 X | 200 µg/0.1 ml | $316.00 | |||
Cdx4 Antibody (H-4) AC | sc-374471 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Cdx4 Antibody (H-4) HRP | sc-374471 HRP | 200 µg/ml | $316.00 | |||
Cdx4 Antibody (H-4) FITC | sc-374471 FITC | 200 µg/ml | $330.00 | |||
Cdx4 Antibody (H-4) PE | sc-374471 PE | 200 µg/ml | $343.00 | |||
Cdx4 Antibody (H-4) Alexa Fluor® 488 | sc-374471 AF488 | 200 µg/ml | $357.00 | |||
Cdx4 Antibody (H-4) Alexa Fluor® 546 | sc-374471 AF546 | 200 µg/ml | $357.00 | |||
Cdx4 Antibody (H-4) Alexa Fluor® 594 | sc-374471 AF594 | 200 µg/ml | $357.00 | |||
Cdx4 Antibody (H-4) Alexa Fluor® 647 | sc-374471 AF647 | 200 µg/ml | $357.00 | |||
Cdx4 Antibody (H-4) Alexa Fluor® 680 | sc-374471 AF680 | 200 µg/ml | $357.00 | |||
Cdx4 Antibody (H-4) Alexa Fluor® 790 | sc-374471 AF790 | 200 µg/ml | $357.00 |