Cdx2 Antibody (B-3): sc-166830
- Cdx2 Antibody (B-3) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 271-313 mapping at the C-terminus of Cdx2 of human origin
- recommended for detection of Cdx2 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cdx2 Antibody (B-3) for WB applications. These reagents are now offered in bundles with Cdx2 Antibody (B-3) (see ordering information below).
QUICK LINKS
Cdx2 Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects Cdx2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cdx2 is a crucial transcription factor that plays a significant role in the development and differentiation of the intestinal epithelium. Cdx2 is primarily expressed in the small intestine and colon, where Cdx2 regulates the expression of genes involved in maintaining the intestinal phenotype and promoting cellular growth. The proper functioning of Cdx2 is vital for the anterior-posterior patterning of the intestinal epithelium, as Cdx2 influences the proliferation and differentiation of cells along the crypt-villus axis. Notably, a decrease in Cdx2 expression has been linked to colorectal tumorigenesis, highlighting Cdx2′s importance in tumor suppression. Cdx2, encoded by the human Cdx2 gene located on chromosome 13q12, consists of 290 amino acids and interacts with various proteins essential for intestinal development and function. anti-Cdx2 antibody (B-3) is an invaluable tool for researchers studying intestinal biology and the molecular mechanisms underlying colorectal cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdx2 Antibody (B-3) References:
- The Cdx-1 and Cdx-2 homeobox genes in the intestine. | Freund, JN., et al. 1998. Biochem Cell Biol. 76: 957-69. PMID: 10392709
- CDX-2, a new marker for adenocarcinoma of gastrointestinal origin. | Li, MK. and Folpe, AL. 2004. Adv Anat Pathol. 11: 101-5. PMID: 15090846
- Nkx6.2 synergizes with Cdx-2 in stimulating proglucagon gene expression. | Wang, PX., et al. 2011. World J Diabetes. 2: 66-74. PMID: 21691557
- The role of CDX2 in inflammatory bowel disease. | Coskun, M. 2014. Dan Med J. 61: B4820. PMID: 24814920
- CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast. | García-Labastida, L., et al. 2014. Biol Res. 47: 43. PMID: 25299496
- CDX-2 Expression in Primary Lung Adenocarcinoma. | Cowan, ML., et al. 2016. Appl Immunohistochem Mol Morphol. 24: 16-9. PMID: 26469326
- NKX2.2, PDX-1 and CDX-2 as potential biomarkers to differentiate well-differentiated neuroendocrine tumors. | Yang, MX., et al. 2018. Biomark Res. 6: 15. PMID: 29713473
- Wnt3a but not CDX-2 expression is associated with differentiated thyroid cancer. | Biagini, GLK., et al. 2022. Rev Assoc Med Bras (1992). 68: 400-404. PMID: 35442371
- CDX-2 expression correlates with clinical outcomes in MSI-H metastatic colorectal cancer patients receiving immune checkpoint inhibitors. | Ziranu, P., et al. 2023. Sci Rep. 13: 4397. PMID: 36928082
- KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2. | Bi, S., et al. 2024. Nat Commun. 15: 5602. PMID: 38961108
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdx2 Antibody (B-3) | sc-166830 | 200 µg/ml | $316.00 | |||
Cdx2 Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-540166 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cdx2 Antibody (B-3): m-IgG1 BP-HRP Bundle | sc-541944 | 200 µg Ab; 20 µg BP | $354.00 |