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Cdk6 Antibody (DCS-90) - Western Blotting - Image 352058
Cdk6 Antibody (DCS-90): sc-56282. Western blot analysis of Cdk6 expression in SCC-4 (A), HeLa (B), NIH/3T3 (C), C6 (D), NCI-H460 (E) and Raji (F) whole cell lysates.
Cdk6 Antibody (DCS-90) - Western Blotting - Image 352058
Cdk6 Antibody (DCS-90): sc-56282. Western blot analysis of Cdk6 expression in SCC-4 (A), HeLa (B), NIH/3T3 (C), C6 (D), NCI-H460 (E) and Raji (F) whole cell lysates.
Cdk6 Antibody (DCS-90) - Western Blotting - Image 14318
Cdk6 Antibody (DCS-90): sc-56282. Western blot analysis of Cdk6 expression in K-562 (A) and Jurkat (B) whole cell lysates.
Cdk6 Antibody (DCS-90) - Western Blotting - Image 413168
Cdk6 Antibody (DCS-90): sc-56282. Western blot analysis of Cdk6 expression in K-562 whole cell lysate. Detection reagent used: m-IgG Fc BP-HRP: sc-525409.
Cdk6 Antibody (DCS-90): sc-56282. Western blot analysis of Cdk6 expression in SCC-4 (A), HeLa (B), NIH/3T3 (C), C6 (D), NCI-H460 (E) and Raji (F) whole cell lysates.

Cdk6 Antibody (DCS-90): sc-56282

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Datasheets
  • Cdk6 Antibody (DCS-90) is a mouse monoclonal IgG1 κ, cited in 11 publications, provided at 200 µg/ml
  • raised against full length Cdk6 of human origin
  • recommended for detection of Cdk6 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with other Cdk types
  • See Cdk6 (DCS-83): sc-53638 for Cdk6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP is the preferred secondary detection reagent for Cdk6 Antibody (DCS-90) for WB applications. This reagent is now offered in a bundle with Cdk6 Antibody (DCS-90) (see ordering information below).
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Additional Cdk Antibodies including Cdk1, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk7, Cdk8 and Cdk9

Cdk6 Antibody (DCS-90) is a mouse monoclonal IgG1 antibody that detects Cdk6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cdk6 plays a crucial role in cell cycle regulation, particularly in the transition from the G1 phase to the S phase, by forming complexes with cyclins D1, D2, and D3. This interaction is vital for the phosphorylation of target substrates that drive cell cycle progression, making anti-Cdk6 antibody (DCS-90) a key player in cellular proliferation and differentiation. The regulation of Cdk6 activity is further influenced by specific cyclin-dependent kinase inhibitors, such as p18 and p19, which can bind to both free and cyclin-bound Cdk6, thereby modulating its function. Understanding the dynamics of Cdk6 and its regulatory mechanisms is essential for elucidating the pathways involved in cell cycle control and their implications in various diseases, including cancer. Cdk6 monoclonal antibody (DCS-90) provides a reliable tool for researchers investigating these critical processes.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Cdk6 Antibody (DCS-90) References:

  1. Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors.  |  Patnaik, A., et al. 2016. Cancer Discov. 6: 740-53. PMID: 27217383
  2. MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR+/HER2- Metastatic Breast Cancer.  |  Dickler, MN., et al. 2017. Clin Cancer Res. 23: 5218-5224. PMID: 28533223
  3. YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling.  |  Xu, X., et al. 2021. Aging Cell. 20: e13465. PMID: 34415667
  4. Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.  |  Ng, YLD., et al. 2022. Nat Commun. 13: 1009. PMID: 35197447
  5. Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.  |  Harris, R., et al. 2022. J Cell Biol. 221: PMID: 35670764
  6. Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.  |  Gao, X., et al. 2023. Cell Rep. 42: 112314. PMID: 37000627
  7. DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway.  |  Fan, H., et al. 2023. Commun Biol. 6: 1041. PMID: 37833461
  8. Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma.  |  Leung, CON., et al. 2023. Nat Commun. 14: 6699. PMID: 37872167
  9. IGF2BP2 Drives Cell Cycle Progression in Triple-Negative Breast Cancer by Recruiting EIF4A1 to Promote the m6A-Modified CDK6 Translation Initiation Process.  |  Xia, T., et al. 2024. Adv Sci (Weinh). 11: e2305142. PMID: 37983610
  10. Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment.  |  Glaviano, A., et al. 2024. Drug Resist Updat. 76: 101103. PMID: 38943828

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cdk6 Antibody (DCS-90)

sc-56282
200 µg/ml
$322.00

Cdk6 Antibody (DCS-90): m-IgG Fc BP-HRP Bundle

sc-551937
200 µg Ab; 10 µg BP
$361.00

Are there any issues with using sc-56282: Cdk6 (DCS-90) mouse monoclonal primary antibody on mouse samples?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-56282 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 4 out of 5 by from Performs well in WesternPerforms well in Western, good signal with A375-STAT1, FM55P, FM55M1, IGR39, IGR37, MeWo, SK-Mel30, Jurkat and MT4 -SCBT Publication Review
Date published: 2015-04-13
Rated 4 out of 5 by from The antibody works well for Western blottingThe antibody works well for Western blotting detecting endogenous Cdk6 from K-562 and Jurkat whole cell lysates. -SCBT QC
Date published: 2014-09-21
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Cdk6 Antibody (DCS-90) is rated 4.0 out of 5 by 2.
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