Cdk6 Antibody (DCS-83): sc-53638
- Cdk6 Antibody (DCS-83) is a mouse monoclonal IgG1 κ, cited in 20 publications, provided at 200 µg/ml
- raised against amino acids 30-65 of Cdk6 of human origin
- Anti-Cdk6 Antibody (DCS-83) is recommended for detection of Cdk6 of mouse, rat and human origin by WB, IP and IF
- Anti-Cdk6 Antibody (DCS-83) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Cdk6 Antibody (DCS-83) for WB applications. This reagent is now offered in a bundle with Cdk6 Antibody (DCS-83) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Cdk6 Antibody (DCS-83) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cdk6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-Cdk6 antibody (DCS-83) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cdk6 plays a crucial role in cell cycle regulation, particularly in the G1/S transition, by partnering with cyclins D1, D2, and D3 to phosphorylate target substrates essential for cell cycle progression. Cdk6′s ability to interact with these cyclins is vital, as this interaction ensures the proper timing of cell division and prevents uncontrolled proliferation, which is a hallmark of cancer. Additionally, specific inhibitors such as p18 and p19 regulate Cdk6 by binding to both free and cyclin-bound forms, thereby modulating activity and maintaining cellular homeostasis. Cdk6 (DCS-83) monoclonal antibody′s versatility in various applications makes this reagent an invaluable tool for researchers studying cell cycle dynamics and related pathways in different species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdk6 Antibody (DCS-83) References:
- CDK6 and p16INK4A in lymphoid malignancies. | Kollmann, K. and Sexl, V. 2013. Oncotarget. 4: 1858-9. PMID: 24161991
- CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation. | Tigan, AS., et al. 2016. Oncogene. 35: 3083-91. PMID: 26500059
- CDK4 and CDK6 Inhibition in Breast Cancer - A New Standard. | Wolff, AC. 2016. N Engl J Med. 375: 1993-1994. PMID: 27959592
- CDK6 Antagonizes p53-Induced Responses during Tumorigenesis. | Bellutti, F., et al. 2018. Cancer Discov. 8: 884-897. PMID: 29899063
- Targeting the CDK6 Dependence of Ph+ Acute Lymphoblastic Leukemia. | Porazzi, P., et al. 2021. Genes (Basel). 12: PMID: 34573335
- CDK6 Degradation Is Counteracted by p16INK4A and p18INK4C in AML. | Schmalzbauer, BS., et al. 2022. Cancers (Basel). 14: PMID: 35326705
- The E2F1-HOXB9/PBX2-CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer. | Zhang, J., et al. 2023. J Pathol. 260: 402-416. PMID: 37272544
- CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma. | Li, GS., et al. 2023. Funct Integr Genomics. 23: 332. PMID: 37950078
- CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver. | Hu, AJ., et al. 2024. Nat Commun. 15: 1091. PMID: 38316780
- Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells. | Mayer, IM., et al. 2024. Blood. 144: 156-170. PMID: 38684032
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk6 Antibody (DCS-83) | sc-53638 | 200 µg/ml | $322.00 | |||
Cdk6 Antibody (DCS-83): m-IgGκ BP-HRP Bundle | sc-551066 | 200 µg Ab; 40 µg BP | $361.00 | |||
Cdk6 Antibody (DCS-83) AC | sc-53638 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Cdk6 Antibody (DCS-83) HRP | sc-53638 HRP | 200 µg/ml | $322.00 | |||
Cdk6 Antibody (DCS-83) FITC | sc-53638 FITC | 200 µg/ml | $336.00 | |||
Cdk6 Antibody (DCS-83) PE | sc-53638 PE | 200 µg/ml | $349.00 | |||
Cdk6 Antibody (DCS-83) Alexa Fluor® 488 | sc-53638 AF488 | 200 µg/ml | $364.00 | |||
Cdk6 Antibody (DCS-83) Alexa Fluor® 546 | sc-53638 AF546 | 200 µg/ml | $364.00 | |||
Cdk6 Antibody (DCS-83) Alexa Fluor® 594 | sc-53638 AF594 | 200 µg/ml | $364.00 | |||
Cdk6 Antibody (DCS-83) Alexa Fluor® 647 | sc-53638 AF647 | 200 µg/ml | $364.00 | |||
Cdk6 Antibody (DCS-83) Alexa Fluor® 680 | sc-53638 AF680 | 200 µg/ml | $364.00 | |||
Cdk6 Antibody (DCS-83) Alexa Fluor® 790 | sc-53638 AF790 | 200 µg/ml | $364.00 |